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Two patients with hairy cell leukemia with massive splenomegaly and severe pancytopenia were treated with recombinant alpha-A interferon (IFN-alpha-2a). There was no significant response to a trial of IFN-alpha-2a (11 and 20 weeks) with respect to blood counts or spleen size. Subsequent treatment with 2'-deoxycoformycin (dCF) for 8 consecutive weeks (4 mg/m2/wk) resulted in normalization of spleen size and a normalization of peripheral blood counts and bone marrow in one patient. The second patient demonstrated a reduction in spleen size and improved blood counts following 9 weeks of dCF therapy but eventually became refractory. This demonstrates that dCF is non-cross-resistant with interferon and confirms the efficacy of dCF in nonsplenectomized patients.
K A Foon, and
G M Nakano, and
C A Koller, and
D L Longo, and
R G Steis
October 1989,
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K A Foon, and
G M Nakano, and
C A Koller, and
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K A Foon, and
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C A Koller, and
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K A Foon, and
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K A Foon, and
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K A Foon, and
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K A Foon, and
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K A Foon, and
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K A Foon, and
G M Nakano, and
C A Koller, and
D L Longo, and
R G Steis
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K A Foon, and
G M Nakano, and
C A Koller, and
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