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We investigated inhibitory effect of various monoclonal antibodies on T-cell-mediated cytotoxicity against autologous hepatocytes in 24 patients with hepatitis B surface antigen/hepatitis B e antigen (HBsAg/HBeAg)-positive chronic active hepatitis. A significant reduction of cytotoxicity index occurred after preincubation of T lymphocytes with anti-Leu 7 (killer-natural killer cells), D1/12 (Ia-positive cells), 5/9 (restricted helper/inducer cells), and MLR4 ("activated" and radiosensitive helper cells) monoclonal antibodies (MAb). Anti-Leu 2a (cytotoxic/suppressor cells) and anti-Leu 3a (helper/inducer cells) MAb did not affect cytotoxic activity. This finding supports the hypothesis that the T cytotoxic reaction in this in vitro system is probably due to two mechanisms: first, spontaneous cell membrane cytotoxicity sustained by anti-Leu-7-positive lymphocytes; and second, specific cytotoxicity mediated by activated Ia-positive cells. We also found that the presence of helper/inducer cells (5/9 positive) appears to be a prerequisite for the cytotoxic reaction.
G F Stefanini, and
M Mazzetti, and
P Zunarelli, and
M Baraldini, and
M Pignatelli, and
G W Canonica, and
F Miglio, and
G Gasbarrini
October 1979,
Clinical and experimental immunology,
G F Stefanini, and
M Mazzetti, and
P Zunarelli, and
M Baraldini, and
M Pignatelli, and
G W Canonica, and
F Miglio, and
G Gasbarrini
August 1978,
Minerva medica,
G F Stefanini, and
M Mazzetti, and
P Zunarelli, and
M Baraldini, and
M Pignatelli, and
G W Canonica, and
F Miglio, and
G Gasbarrini
December 1974,
Nature,
G F Stefanini, and
M Mazzetti, and
P Zunarelli, and
M Baraldini, and
M Pignatelli, and
G W Canonica, and
F Miglio, and
G Gasbarrini
April 1975,
Proceedings of the National Academy of Sciences of the United States of America,
G F Stefanini, and
M Mazzetti, and
P Zunarelli, and
M Baraldini, and
M Pignatelli, and
G W Canonica, and
F Miglio, and
G Gasbarrini
January 1975,
Tijdschrift voor gastro-enterologie,
G F Stefanini, and
M Mazzetti, and
P Zunarelli, and
M Baraldini, and
M Pignatelli, and
G W Canonica, and
F Miglio, and
G Gasbarrini
February 1984,
Gut,
G F Stefanini, and
M Mazzetti, and
P Zunarelli, and
M Baraldini, and
M Pignatelli, and
G W Canonica, and
F Miglio, and
G Gasbarrini
January 1989,
The Korean journal of internal medicine,
G F Stefanini, and
M Mazzetti, and
P Zunarelli, and
M Baraldini, and
M Pignatelli, and
G W Canonica, and
F Miglio, and
G Gasbarrini
September 1981,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
G F Stefanini, and
M Mazzetti, and
P Zunarelli, and
M Baraldini, and
M Pignatelli, and
G W Canonica, and
F Miglio, and
G Gasbarrini
May 1983,
Journal of pediatric gastroenterology and nutrition,
G F Stefanini, and
M Mazzetti, and
P Zunarelli, and
M Baraldini, and
M Pignatelli, and
G W Canonica, and
F Miglio, and
G Gasbarrini
December 1982,
Gut,
