Biomaterial Database

Nano-sized zeolite-like metal-organic frameworks induced hematological effects on red blood cell. 2022

Fang Hao, and Xiu-Ping Yan

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; International Joint Laboratory on Food Safety, Jiangnan University, Wuxi 214122, China; Institute of Analytical Food Safety, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China.

Understanding the toxicity of metal-organic frameworks (MOFs) is important for improving their biocompatibility in further applications, especially the hematotoxicity of MOFs due to the unavoidable contact of MOFs with blood in biomedical science. Here we report the hematotoxicity and underlying mechanisms of nano-sized zeolite-like MOFs ZIF-8 and ZIF-67 because of their wide applications in biomedical science. ZIF-67 induced significant hemolysis of red blood cell (Rb) through breaking the structure of membrane due to the generation of free radicals, whereas ZIF-8 was hematocompatible. ZIF-67 was thus internalized by Rb and then bound with hemoglobin via hydrogen bond and van der Waals force, which influenced the structure and function of hemoglobin in accompany with heme release. These findings reveal the detailed mechanism of the hematological effects of MOFs on Rb and are helpful to the assessment of the toxicity and potential health risks of MOFs and the design of biosafe MOFs for biomedical applications.

UI	MeSH Term	Description	Entries
D004912	Erythrocytes	Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.	Blood Cells, Red,Blood Corpuscles, Red,Red Blood Cells,Red Blood Corpuscles,Blood Cell, Red,Blood Corpuscle, Red,Erythrocyte,Red Blood Cell,Red Blood Corpuscle
D006454	Hemoglobins	The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.	Eryhem,Ferrous Hemoglobin,Hemoglobin,Hemoglobin, Ferrous
D000073396	Metal-Organic Frameworks	Supramolecular networks that consist of ordered arrangements of organic electron donor linkers (usually ditopic or polytopic organic carboxylates) and metal cations. They can have an extremely high surface area and adjustable pore size that allows for the insertion of other molecules capable of various functions such as catalysis, capture of carbon dioxide, and drug delivery.	Metal Organic Framework,Metal-Organic Framework,Porous Coordination Polymer,Covalent Organic Framework,Porous Coordination Networks,Porous Coordination Polymers,Coordination Networks, Porous,Coordination Polymer, Porous,Coordination Polymers, Porous,Framework, Covalent Organic,Framework, Metal Organic,Framework, Metal-Organic,Frameworks, Metal-Organic,Metal Organic Frameworks,Networks, Porous Coordination,Organic Framework, Covalent,Organic Framework, Metal,Polymer, Porous Coordination,Polymers, Porous Coordination
D017641	Zeolites	Zeolites. A group of crystalline, hydrated alkali-aluminum silicates. They occur naturally in sedimentary and volcanic rocks, altered basalts, ores, and clay deposits. Some 40 known zeolite minerals and a great number of synthetic zeolites are available commercially. (From Merck Index, 11th ed)	Zeolite