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The cell line 5637 which originated from a human urinary bladder carcinoma is known to produce GM-CSF and Multi-CSF ectopically. Determination of cell surface antigens defined by monoclonal antibodies was recently reported. Here we report on the ultrastructure and karyology of this CSF secreting cell line. At the ultrastructural level the monolayer in vitro culture and the solid tumors formed in nude mice showed all characteristics consistent with a well-differentiated transitional cell carcinoma (TCC). A subclone was found to grow in suspension and did not secrete any CSF activity. High resolution chromosome analysis revealed chromosomal abnormalities which agreed only in few particulars with nonrandom chromosomal aberrations usually found in TCC. Analysis of the cytogenetic results showed that nearly all structural abnormalities present are known to be associated with acute or chronic human leukemia. The possibility that the ectopic production of CSF in this cell line may be correlated to one or more of the described chromosomal aberrations is discussed.
K H Pflüger, and
H D Probeck, and
G Adler, and
D Stach-Machado, and
H Kapmeyer, and
K Havemann
April 1986,
Proceedings of the National Academy of Sciences of the United States of America,
K H Pflüger, and
H D Probeck, and
G Adler, and
D Stach-Machado, and
H Kapmeyer, and
K Havemann
January 1987,
Journal of cancer research and clinical oncology,
K H Pflüger, and
H D Probeck, and
G Adler, and
D Stach-Machado, and
H Kapmeyer, and
K Havemann
January 1990,
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie,
K H Pflüger, and
H D Probeck, and
G Adler, and
D Stach-Machado, and
H Kapmeyer, and
K Havemann
January 1993,
Virchows Archiv. A, Pathological anatomy and histopathology,
K H Pflüger, and
H D Probeck, and
G Adler, and
D Stach-Machado, and
H Kapmeyer, and
K Havemann
January 1981,
Cellular and molecular biology, including cyto-enzymology,
K H Pflüger, and
H D Probeck, and
G Adler, and
D Stach-Machado, and
H Kapmeyer, and
K Havemann
July 1994,
Nihon Hinyokika Gakkai zasshi. The japanese journal of urology,
K H Pflüger, and
H D Probeck, and
G Adler, and
D Stach-Machado, and
H Kapmeyer, and
K Havemann
June 2001,
Hinyokika kiyo. Acta urologica Japonica,
K H Pflüger, and
H D Probeck, and
G Adler, and
D Stach-Machado, and
H Kapmeyer, and
K Havemann
July 1992,
The Journal of pharmacology and experimental therapeutics,
K H Pflüger, and
H D Probeck, and
G Adler, and
D Stach-Machado, and
H Kapmeyer, and
K Havemann
February 2005,
Hinyokika kiyo. Acta urologica Japonica,
K H Pflüger, and
H D Probeck, and
G Adler, and
D Stach-Machado, and
H Kapmeyer, and
K Havemann
November 1986,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
