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Non-cytotoxic sera obtained from post-partum primiparous and multiparous women were examined by a rosette inhibition technique for the presence of antibodies mediating blockade of human B lymphocyte Fc receptors. Selective activity was demonstrated against a panel of normal human B lymphocytes and lymphocytes from patients with chronic lymphocytic leukaemia (CLL). A pattern of specific activity was found in sera and in their IgG fractions, which was not accounted for by antibodies directed to known HLA-A, -B or -DR antigens. Several sera were identified with selective activity in this assay. As the results of testing sera in a direct binding assay correlated with those of the EA inhibition assay, and since EA inhibitory activity occurred in F(ab')2 fractions of sera, it is possible that these non-cytotoxic antibodies bind directly to B cell surface antigens. Sera may therefore have been identified which possess antibodies to hitherto undefined HLA antigens.
A M MacLeod, and
A J Mather, and
R J Mason, and
K N Stewart, and
D A Power, and
A Innes, and
G R Catto
December 1982,
Journal of immunology (Baltimore, Md. : 1950),
A M MacLeod, and
A J Mather, and
R J Mason, and
K N Stewart, and
D A Power, and
A Innes, and
G R Catto
August 1977,
Proceedings of the National Academy of Sciences of the United States of America,
A M MacLeod, and
A J Mather, and
R J Mason, and
K N Stewart, and
D A Power, and
A Innes, and
G R Catto
December 2003,
International journal of molecular medicine,
A M MacLeod, and
A J Mather, and
R J Mason, and
K N Stewart, and
D A Power, and
A Innes, and
G R Catto
December 1987,
Human immunology,
A M MacLeod, and
A J Mather, and
R J Mason, and
K N Stewart, and
D A Power, and
A Innes, and
G R Catto
November 1988,
Tissue antigens,
A M MacLeod, and
A J Mather, and
R J Mason, and
K N Stewart, and
D A Power, and
A Innes, and
G R Catto
September 1976,
European journal of immunology,
A M MacLeod, and
A J Mather, and
R J Mason, and
K N Stewart, and
D A Power, and
A Innes, and
G R Catto
April 1988,
Clinical science (London, England : 1979),
A M MacLeod, and
A J Mather, and
R J Mason, and
K N Stewart, and
D A Power, and
A Innes, and
G R Catto
December 2006,
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation,
A M MacLeod, and
A J Mather, and
R J Mason, and
K N Stewart, and
D A Power, and
A Innes, and
G R Catto
September 1996,
Transplantation,
A M MacLeod, and
A J Mather, and
R J Mason, and
K N Stewart, and
D A Power, and
A Innes, and
G R Catto
February 1994,
Transplantation,
