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The distribution of the recently described HLA-DP antigens was examined in a population of patients with pauciarticular juvenile rheumatoid arthritis and iridocyclitis, in an attempt to further characterize the immunogenetically determined susceptibility to this disease. There was a significantly increased frequency of the HLA-DPw2 antigen in the patients compared with the controls (67% versus 34%; odds ratio 3.9, P = 0.003 by Fisher's exact test). Population studies and family studies showed that this association with HLA-DPw2 was not secondary to linkage disequilibrium with the previously defined HLA-D region markers of disease (HLA-DR5 and HLA-DRw8) in these patients. These data raise the possibility that susceptibility to this form of juvenile rheumatoid arthritis may be regulated by more than one HLA-linked gene.
R W Hoffman, and
S Shaw, and
L C Francis, and
M G Larson, and
R A Petersen, and
L T Chylack, and
D N Glass
December 1989,
Proceedings of the National Academy of Sciences of the United States of America,
R W Hoffman, and
S Shaw, and
L C Francis, and
M G Larson, and
R A Petersen, and
L T Chylack, and
D N Glass
November 1991,
The Journal of rheumatology,
R W Hoffman, and
S Shaw, and
L C Francis, and
M G Larson, and
R A Petersen, and
L T Chylack, and
D N Glass
January 1993,
Immunogenetics,
R W Hoffman, and
S Shaw, and
L C Francis, and
M G Larson, and
R A Petersen, and
L T Chylack, and
D N Glass
December 1990,
Arthritis and rheumatism,
R W Hoffman, and
S Shaw, and
L C Francis, and
M G Larson, and
R A Petersen, and
L T Chylack, and
D N Glass
October 1983,
Annales de pediatrie,
R W Hoffman, and
S Shaw, and
L C Francis, and
M G Larson, and
R A Petersen, and
L T Chylack, and
D N Glass
January 1990,
Immunogenetics,
R W Hoffman, and
S Shaw, and
L C Francis, and
M G Larson, and
R A Petersen, and
L T Chylack, and
D N Glass
January 1990,
Revmatologiia (Moscow, Russia),
R W Hoffman, and
S Shaw, and
L C Francis, and
M G Larson, and
R A Petersen, and
L T Chylack, and
D N Glass
April 1987,
Minerva pediatrica,
R W Hoffman, and
S Shaw, and
L C Francis, and
M G Larson, and
R A Petersen, and
L T Chylack, and
D N Glass
May 1971,
The Journal of pediatrics,
R W Hoffman, and
S Shaw, and
L C Francis, and
M G Larson, and
R A Petersen, and
L T Chylack, and
D N Glass
July 1991,
Tissue antigens,
