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Early Multicenter Experience With Imipenem-Cilastatin-Relebactam for Multidrug-Resistant Gram-Negative Infections. 2021
Nicholas Rebold, and
Taylor Morrisette, and
Abdalhamid M Lagnf, and
Sara Alosaimy, and
Dana Holger, and
Katie Barber, and
Julie Ann Justo, and
Kayla Antosz, and
Travis J Carlson, and
Jeremy J Frens, and
Mark Biagi, and
Wesley D Kufel, and
William J Moore, and
Nicholas Mercuro, and
Brian R Raux, and
Michael J Rybak
Anti-Infective Research Laboratory, Department of Pharmacy Practice, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan, USA.
A multicenter case series of 21 patients were treated with imipenem-cilastatin-relebactam. There were mixed infection sources, with pulmonary infections (11/21,52%) composing the majority. The primary pathogen was Pseudomonas aeruginosa (16/21, 76%), and 15/16 (94%) isolates were multidrug-resistant. Thirty-day survival occurred in 14/21 (67%) patients. Two patients experienced adverse effects.
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