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Leprosy in the mangabey monkey is an experimental model which is similar both clinically and histologically to human lepromatous leprosy. The immunopathology of these diseases was compared using monoclonal antibodies against T lymphocyte subpopulations in frozen tissue sections with an immunoperoxidase technique. In both mangabey and human lepromatous granulomas OKT4 (or Leu 3a) and Leu 2a cells were scattered among macrophages with greater numbers of Leu 2a as compared with OKT4 (or Leu 3a) cells. The results suggest that from an immunopathological standpoint experimental leprosy in mangabeys will provide a suitable model for the investigation of the pathogenesis of human lepromatous leprosy and for the evaluation of new antileprosy vaccines.
R L Modlin, and
L D Ormerod, and
G P Walsh, and
T H Rea, and
W M Meyers, and
C H Binford, and
L N Martin, and
R H Wolf, and
B J Gormus
September 1982,
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association,
R L Modlin, and
L D Ormerod, and
G P Walsh, and
T H Rea, and
W M Meyers, and
C H Binford, and
L N Martin, and
R H Wolf, and
B J Gormus
March 1985,
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association,
R L Modlin, and
L D Ormerod, and
G P Walsh, and
T H Rea, and
W M Meyers, and
C H Binford, and
L N Martin, and
R H Wolf, and
B J Gormus
July 1983,
Clinical and experimental immunology,
R L Modlin, and
L D Ormerod, and
G P Walsh, and
T H Rea, and
W M Meyers, and
C H Binford, and
L N Martin, and
R H Wolf, and
B J Gormus
June 2008,
International journal of dermatology,
R L Modlin, and
L D Ormerod, and
G P Walsh, and
T H Rea, and
W M Meyers, and
C H Binford, and
L N Martin, and
R H Wolf, and
B J Gormus
June 1984,
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association,
R L Modlin, and
L D Ormerod, and
G P Walsh, and
T H Rea, and
W M Meyers, and
C H Binford, and
L N Martin, and
R H Wolf, and
B J Gormus
June 1993,
Veterinary immunology and immunopathology,
R L Modlin, and
L D Ormerod, and
G P Walsh, and
T H Rea, and
W M Meyers, and
C H Binford, and
L N Martin, and
R H Wolf, and
B J Gormus
March 1988,
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association,
R L Modlin, and
L D Ormerod, and
G P Walsh, and
T H Rea, and
W M Meyers, and
C H Binford, and
L N Martin, and
R H Wolf, and
B J Gormus
June 1990,
Journal of applied toxicology : JAT,
R L Modlin, and
L D Ormerod, and
G P Walsh, and
T H Rea, and
W M Meyers, and
C H Binford, and
L N Martin, and
R H Wolf, and
B J Gormus
January 1988,
Medicina cutanea ibero-latino-americana,
R L Modlin, and
L D Ormerod, and
G P Walsh, and
T H Rea, and
W M Meyers, and
C H Binford, and
L N Martin, and
R H Wolf, and
B J Gormus
April 1982,
Journal of clinical immunology,
