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Thirty-six unrelated Danish patients with pauciarticular Juvenile Chronic Arthritis (PJCA) and 120 controls were typed for HLA-DPw1-w6 and the local specificity CDPHEI with bulk-expanded Primed Lymphocyte Typing (PLT) cells. The frequency of HLA-DPw2 was 52.8% in PJCA patients and 16.7% in controls (relative risk, RR = 4.5; P less than 0.001). The antigens HLA-Dw5 and/or Dw8 were present in 50% of the patients and in 21.3% of the controls (RR = 4.2; p less than 10(-3)). DPw2 was not associated (in linkage disequilibrium) with Dw5/w8 in patients or in controls, and the DP and D associations with PJCA were independent of each other. However, the combined presence of DPw2 and Dw5 and/or Dw8 gave a significantly higher risk of PJCA than each antigen alone indicating interaction of DP and DR gene products. PJCA is the first disease definitely found to be associated with a DP antigen.
N Odum, and
N Morling, and
J Friis, and
C Heilmann, and
J J Hyldig-Nielsen, and
B K Jakobsen, and
F K Pedersen, and
P Platz, and
L P Ryder, and
A Svejgaard
April 1994,
Annals of the rheumatic diseases,
N Odum, and
N Morling, and
J Friis, and
C Heilmann, and
J J Hyldig-Nielsen, and
B K Jakobsen, and
F K Pedersen, and
P Platz, and
L P Ryder, and
A Svejgaard
January 1993,
Immunogenetics,
N Odum, and
N Morling, and
J Friis, and
C Heilmann, and
J J Hyldig-Nielsen, and
B K Jakobsen, and
F K Pedersen, and
P Platz, and
L P Ryder, and
A Svejgaard
January 1994,
Immunogenetics,
N Odum, and
N Morling, and
J Friis, and
C Heilmann, and
J J Hyldig-Nielsen, and
B K Jakobsen, and
F K Pedersen, and
P Platz, and
L P Ryder, and
A Svejgaard
August 1999,
Annals of the rheumatic diseases,
N Odum, and
N Morling, and
J Friis, and
C Heilmann, and
J J Hyldig-Nielsen, and
B K Jakobsen, and
F K Pedersen, and
P Platz, and
L P Ryder, and
A Svejgaard
May 1992,
European journal of pediatrics,
N Odum, and
N Morling, and
J Friis, and
C Heilmann, and
J J Hyldig-Nielsen, and
B K Jakobsen, and
F K Pedersen, and
P Platz, and
L P Ryder, and
A Svejgaard
October 1991,
Tijdschrift voor kindergeneeskunde,
N Odum, and
N Morling, and
J Friis, and
C Heilmann, and
J J Hyldig-Nielsen, and
B K Jakobsen, and
F K Pedersen, and
P Platz, and
L P Ryder, and
A Svejgaard
December 1993,
Clinical rheumatology,
N Odum, and
N Morling, and
J Friis, and
C Heilmann, and
J J Hyldig-Nielsen, and
B K Jakobsen, and
F K Pedersen, and
P Platz, and
L P Ryder, and
A Svejgaard
April 1985,
Tissue antigens,
N Odum, and
N Morling, and
J Friis, and
C Heilmann, and
J J Hyldig-Nielsen, and
B K Jakobsen, and
F K Pedersen, and
P Platz, and
L P Ryder, and
A Svejgaard
October 1991,
Arthritis and rheumatism,
N Odum, and
N Morling, and
J Friis, and
C Heilmann, and
J J Hyldig-Nielsen, and
B K Jakobsen, and
F K Pedersen, and
P Platz, and
L P Ryder, and
A Svejgaard
June 1987,
The Journal of rheumatology,
