Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000071199
NLR Family, Pyrin Domain-Containing 3 Protein
An NLR protein that contains an N-terminal PYRIN DOMAIN and ATP-binding site and 9 C-terminal LEUCINE-rich repeats; it is expressed primarily by MACROPHAGES. It is a core component of the INFLAMMASOME and directs its assembly in response to pathogen infection and damage-associated stimuli. Mutations in the NLRP3 gene are associated with FAMILIAL COLD AUTOINFLAMMATORY SYNDROME.
Cold Autoinflammatory Syndrome 1 Protein,NACHT, LRR and PYD Domains-Containing Protein 3,NLRP3 Protein,NACHT, LRR and PYD Domains Containing Protein 3,NLR Family, Pyrin Domain Containing 3 Protein
D058847
Inflammasomes
Multiprotein complexes that mediate the activation of CASPASE-1. Dysregulation of inflammasomes has also been linked to a number of autoinflammatory and autoimmune disorders.
Inflammasome,Pyroptosome,Pyroptosomes
Related Publications
Wei Li, and
Tian Wang, and
Wen-Bin Huang, and
Fang-Gu Li, and
Juan-Hua Quan, and
Ge Shi, and
Christos C Zouboulis, and
Yi-Ming Fan