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Long-term effects of MPTP on striatal dopamine (DA) content and the influence of aging on the recovery were investigated in mice. Male C57BL/6J mice, young (2-month-old) and mature (10-month-old), were used. Two different dosage schedules of MPTP, i.e., 4 doses subcutaneous injections of 20 mg/kg each, and 4 doses subcutaneous injections of 40 mg/kg each, were given to both young and mature mice at 12-h intervals. Assays of striatal DA and 3,4-dihydroxyphenylacetic acid (DOPAC) content were performed 1 week, 1 month, 2 months, and 3 months after the last injection of MPTP. MPTP produced a marked reduction (-75% to -80%) of striatal DA content in both young and mature mice 1 week after the last injection of MPTP. In young mice, the striatal DA content showed a partial recovery in the subsequent stages studied. In contrast, no apparent recovery occurred in mature mice until as long as 3 months after the last injection. The results suggest that mice have a capacity for partial recovery of the striatal DA contents which was depleted by MPTP, and this capacity for recovery appears to be impaired in mature mice.
T Saitoh, and
K Niijima, and
Y Mizuno
January 1990,
General pharmacology,
T Saitoh, and
K Niijima, and
Y Mizuno
January 1985,
Progress in neuro-psychopharmacology & biological psychiatry,
T Saitoh, and
K Niijima, and
Y Mizuno
March 1986,
Brain research,
T Saitoh, and
K Niijima, and
Y Mizuno
March 1988,
Toxicology letters,
T Saitoh, and
K Niijima, and
Y Mizuno
August 1986,
Neuropharmacology,
T Saitoh, and
K Niijima, and
Y Mizuno
January 1991,
Neurotoxicology,
T Saitoh, and
K Niijima, and
Y Mizuno
June 2003,
Metabolic brain disease,
T Saitoh, and
K Niijima, and
Y Mizuno
March 1991,
Toxicology,
T Saitoh, and
K Niijima, and
Y Mizuno
May 1985,
The New England journal of medicine,
T Saitoh, and
K Niijima, and
Y Mizuno
November 1990,
Brain research,
