U-model, which is a control-oriented model set with the property of generally facilitate nonlinearity dynamic inversion/cancellation, has been introduced to the Disturbance Observer-Based control (DOBC) methods to improve the performance of the nonlinear systems in this paper. A general DOB based U-Control (DOBUC) framework is proposed to improve the disturbance attenuation capability of U-controller for both linear and nonlinear systems combined with (based on) the U-model-based dynamic inversion which expands the classical linear disturbance observer control to general nonlinear systems. The proposed two-step DOBUC design procedures in which the design of DOB and U-controller are totally independent and separated, enables the establishment of global exponential stability without being subject to disturbances and uncertainties. Comparative simulation experiments with Nonlinear DOBC in controlling Wind Energy Conversion Systems (WECS) and Permanent Magnet Synchronous Motors (PMSM) demonstrated the proposed method.