BIOMAT Database Logo BIOMAT Database Logo

Role of glyoxalase 1 in methylglyoxal detoxification-the broad player of psychiatric disorders. 2022

Kazuya Toriumi, and Mitsuhiro Miyashita, and Kazuhiro Suzuki, and Koichi Tabata, and Yasue Horiuchi, and Hiroaki Ishida, and Masanari Itokawa, and Makoto Arai
Schizophrenia Research Project, Department of Psychiatry and Behavioral Sciences, Tokyo Metropolitan Institute of Medical Science, Tokyo, 156-8506, Japan.

Methylglyoxal (MG) is a highly reactive α-ketoaldehyde formed endogenously as a byproduct of the glycolytic pathway. To remove MG, various detoxification systems work together in vivo, including the glyoxalase system, which enzymatically degrades MG using glyoxalase 1 (GLO1) and GLO2. Recently, numerous reports have shown that GLO1 expression and MG accumulation in the brain are involved in the pathogenesis of psychiatric disorders, such as anxiety disorder, depression, autism, and schizophrenia. Furthermore, it has been reported that GLO1 inhibitors may be promising drugs for the treatment of psychiatric disorders. In this review, we discuss the recent findings of the effects of altered GLO1 function on mental behavior, especially focusing on results obtained from animal models.

UI MeSH Term Description Entries
D007791 Lactoylglutathione Lyase An enzyme that catalyzes the interconversion of methylglyoxal and lactate, with glutathione serving as a coenzyme. EC 4.4.1.5. Glyoxalase I,Lactoyl Glutathione Lyase,Methylglyoxalase,Glutathione Lyase, Lactoyl,Lyase, Lactoyl Glutathione,Lyase, Lactoylglutathione
D011765 Pyruvaldehyde An organic compound used often as a reagent in organic synthesis, as a flavoring agent, and in tanning. It has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated cell preparations, in various culture media, and in vivo in certain animals. Acetylformaldehyde,Methylglyoxal,Oxopropanal,Pyruvic Aldehyde,Aldehyde, Pyruvic
D001921 Brain The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM. Encephalon
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012559 Schizophrenia A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior. Dementia Praecox,Schizophrenic Disorders,Disorder, Schizophrenic,Disorders, Schizophrenic,Schizophrenias,Schizophrenic Disorder

Related Publications

Kazuya Toriumi, and Mitsuhiro Miyashita, and Kazuhiro Suzuki, and Koichi Tabata, and Yasue Horiuchi, and Hiroaki Ishida, and Masanari Itokawa, and Makoto Arai
The critical role of methylglyoxal and glyoxalase 1 in diabetic nephropathy.
January 2014, Diabetes,
Kazuya Toriumi, and Mitsuhiro Miyashita, and Kazuhiro Suzuki, and Koichi Tabata, and Yasue Horiuchi, and Hiroaki Ishida, and Masanari Itokawa, and Makoto Arai
Methylglyoxal, glyoxalase 1 and the dicarbonyl proteome.
April 2012, Amino acids,
Kazuya Toriumi, and Mitsuhiro Miyashita, and Kazuhiro Suzuki, and Koichi Tabata, and Yasue Horiuchi, and Hiroaki Ishida, and Masanari Itokawa, and Makoto Arai
Zn2+ dependent glyoxalase I plays the major role in methylglyoxal detoxification and salinity stress tolerance in plants.
January 2020, PloS one,
Kazuya Toriumi, and Mitsuhiro Miyashita, and Kazuhiro Suzuki, and Koichi Tabata, and Yasue Horiuchi, and Hiroaki Ishida, and Masanari Itokawa, and Makoto Arai
Possible role of methylglyoxal and glyoxalase in arthritis.
April 2014, Biochemical Society transactions,
Kazuya Toriumi, and Mitsuhiro Miyashita, and Kazuhiro Suzuki, and Koichi Tabata, and Yasue Horiuchi, and Hiroaki Ishida, and Masanari Itokawa, and Makoto Arai
Glyoxalase I gene deletion mutants of Leishmania donovani exhibit reduced methylglyoxal detoxification.
August 2009, PloS one,
Kazuya Toriumi, and Mitsuhiro Miyashita, and Kazuhiro Suzuki, and Koichi Tabata, and Yasue Horiuchi, and Hiroaki Ishida, and Masanari Itokawa, and Makoto Arai
Methylglyoxal-Glyoxalase 1 Balance: The Root of Vascular Damage.
January 2017, International journal of molecular sciences,
Kazuya Toriumi, and Mitsuhiro Miyashita, and Kazuhiro Suzuki, and Koichi Tabata, and Yasue Horiuchi, and Hiroaki Ishida, and Masanari Itokawa, and Makoto Arai
PARK7 Catalyzes Stereospecific Detoxification of Methylglyoxal Consistent with Glyoxalase and Not Deglycase Function.
November 2023, Biochemistry,
Kazuya Toriumi, and Mitsuhiro Miyashita, and Kazuhiro Suzuki, and Koichi Tabata, and Yasue Horiuchi, and Hiroaki Ishida, and Masanari Itokawa, and Makoto Arai
Altered glyoxalase 1 expression in psychiatric disorders: cause or consequence?
May 2011, Seminars in cell & developmental biology,
Kazuya Toriumi, and Mitsuhiro Miyashita, and Kazuhiro Suzuki, and Koichi Tabata, and Yasue Horiuchi, and Hiroaki Ishida, and Masanari Itokawa, and Makoto Arai
The role of glyoxalase I in the detoxification of methylglyoxal and in the activation of the KefB K+ efflux system in Escherichia coli.
February 1998, Molecular microbiology,
Kazuya Toriumi, and Mitsuhiro Miyashita, and Kazuhiro Suzuki, and Koichi Tabata, and Yasue Horiuchi, and Hiroaki Ishida, and Masanari Itokawa, and Makoto Arai
Presence of unique glyoxalase III proteins in plants indicates the existence of shorter route for methylglyoxal detoxification.
January 2016, Scientific reports,
Copied contents to your clipboard!