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An investigation of the structural and thermodynamical modifications induced by gamma-irradiation in model membranes is reported. Differential scanning calorimetry and X-ray diffraction were used to study the different phases and associated transitions of distearoylphosphatidylcholine multilamellar liposomes after 60Co gamma-irradiation. Changes were observed in the shape of the calorimetric peaks and in the corresponding phase transition temperatures. In particular a shoulder was observed at about 20 kGy. The three phases characteristic of lecithins with identical acyl chains were detected also for the highest radiation dose. The formation of lysolecithin and stearic acid upon phospholipid degradation was observed. The lysolecithin concentration increases as a function of irradiation dose, until a saturation value is reached at 40 kGy. These results correlate quite well with those obtained for interlayer and interchain distances and for the width of the main phase transition calorimetric peak. At the highest dose (approximately equal to 80 kGy) cross-linked adjacent radicals and other molecular species are also formed. Appreciable differences, and some similarities, in the behaviour of DSPC and DPPC liposomes under gamma-irradiation were observed.
G Albertini, and
E Fanelli, and
L Guidoni, and
F Ianzini, and
P Mariani, and
R Masella, and
F Rustichelli, and
V Viti
March 2015,
Journal of advanced research,
G Albertini, and
E Fanelli, and
L Guidoni, and
F Ianzini, and
P Mariani, and
R Masella, and
F Rustichelli, and
V Viti
January 1993,
Annales pharmaceutiques francaises,
G Albertini, and
E Fanelli, and
L Guidoni, and
F Ianzini, and
P Mariani, and
R Masella, and
F Rustichelli, and
V Viti
March 1981,
Biochimica et biophysica acta,
G Albertini, and
E Fanelli, and
L Guidoni, and
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P Mariani, and
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V Viti
July 1994,
Journal of pharmaceutical sciences,
G Albertini, and
E Fanelli, and
L Guidoni, and
F Ianzini, and
P Mariani, and
R Masella, and
F Rustichelli, and
V Viti
April 1984,
Radiation research,
G Albertini, and
E Fanelli, and
L Guidoni, and
F Ianzini, and
P Mariani, and
R Masella, and
F Rustichelli, and
V Viti
January 1973,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
G Albertini, and
E Fanelli, and
L Guidoni, and
F Ianzini, and
P Mariani, and
R Masella, and
F Rustichelli, and
V Viti
April 2023,
Biomolecules,
G Albertini, and
E Fanelli, and
L Guidoni, and
F Ianzini, and
P Mariani, and
R Masella, and
F Rustichelli, and
V Viti
January 1954,
Vestnik rentgenologii i radiologii,
G Albertini, and
E Fanelli, and
L Guidoni, and
F Ianzini, and
P Mariani, and
R Masella, and
F Rustichelli, and
V Viti
April 1965,
Minerva chirurgica,
G Albertini, and
E Fanelli, and
L Guidoni, and
F Ianzini, and
P Mariani, and
R Masella, and
F Rustichelli, and
V Viti
January 1984,
Biochimica et biophysica acta,
