-transparent.png){kind=logo}
No-carrier-added (NCA) (+/-)-N-(3-[18F]Fluoropropyl)-N-normetazocine (2) was synthesized by N-alkylation of (+/-)-N-normetazocine (1) with NCA 1-[18F]fluoro-3-iodopropane in an overall radiochemical yield of 10% (EOB) with a mass of 3.5 nmol in a synthesis time of 90 min from end of bombardment (EOB). PET studies of 2 in a baboon did not indicate specificity for opiate receptor sites alone: The activity declined rapidly in the striatum, the frontal cortex and the cerebellum. The baboon total arterial plasma radioactivity clearance was very rapid and the metabolism of compound 2 in plasma was also very rapid. These results suggest that compound 2 is not a suitable radioligand for imaging opiate receptors in the human brain by positron tomography.
C Y Shiue, and
R R Teng, and
L Q Bai, and
A P Wolf, and
C D Arnett, and
E J Simon
August 2002,
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine,
C Y Shiue, and
R R Teng, and
L Q Bai, and
A P Wolf, and
C D Arnett, and
E J Simon
September 1985,
Research communications in chemical pathology and pharmacology,
C Y Shiue, and
R R Teng, and
L Q Bai, and
A P Wolf, and
C D Arnett, and
E J Simon
January 1986,
International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes,
C Y Shiue, and
R R Teng, and
L Q Bai, and
A P Wolf, and
C D Arnett, and
E J Simon
February 1992,
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology,
C Y Shiue, and
R R Teng, and
L Q Bai, and
A P Wolf, and
C D Arnett, and
E J Simon
January 1990,
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology,
C Y Shiue, and
R R Teng, and
L Q Bai, and
A P Wolf, and
C D Arnett, and
E J Simon
July 1984,
The International journal of applied radiation and isotopes,
C Y Shiue, and
R R Teng, and
L Q Bai, and
A P Wolf, and
C D Arnett, and
E J Simon
April 1985,
The International journal of applied radiation and isotopes,
C Y Shiue, and
R R Teng, and
L Q Bai, and
A P Wolf, and
C D Arnett, and
E J Simon
January 2017,
Annals of nuclear medicine,
C Y Shiue, and
R R Teng, and
L Q Bai, and
A P Wolf, and
C D Arnett, and
E J Simon
January 2023,
Nuclear medicine and biology,
C Y Shiue, and
R R Teng, and
L Q Bai, and
A P Wolf, and
C D Arnett, and
E J Simon
October 2003,
Nuclear medicine and biology,
