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To investigate the effect of fat saturation (FatSat) on quantitative UTE imaging of variable knee tissues on a 3T scanner. Three quantitative UTE imaging techniques, including the UTE multi-echo sequence for measurement, the adiabatic T1ρ prepared UTE sequence for T1ρ measurement, and the magnetization transfer (MT)-prepared UTE sequence for MT ratio (MTR) and macromolecular proton fraction (MMF) measurements were used in this study. Twelve samples of cartilage and twelve samples of meniscus, as well as six whole knee cadaveric specimens, were imaged with the three above-mentioned UTE sequences with and without FatSat. The difference, correlation, and agreement between the UTE measurements with and without FatSat were calculated to investigate the effects of FatSat on quantification. Fat was well-suppressed using all three UTE sequences when FatSat was deployed. For the small sample study, the quantification difference ratio (QDR) values of all the measured biomarkers ranged from 0.7% to 12.6%, whereas for the whole knee joint specimen study, the QDR values ranged from 0.2% to 12.0%. Except for T1ρ in muscle and MMF in meniscus (p > 0.05), most of the measurements showed statistical differences for T1ρ , MTR, and MMF (p < 0.05) between FatSat and non-FatSat scans. Most of the measurements for showed no significant differences (p > 0.05). Strong correlations were found for all the biomarkers between measurements with and without FatSat. The UTE biomarkers showed good correlation and agreement with some slight differences between the scans with and without FatSat.
Yanjun Chen, and
Liang Li, and
Nicole Le, and
Eric Y Chang, and
Wenhua Huang, and
Ya-Jun Ma
August 2009,
Magnetic resonance in medicine,
Yanjun Chen, and
Liang Li, and
Nicole Le, and
Eric Y Chang, and
Wenhua Huang, and
Ya-Jun Ma
November 1990,
AJR. American journal of roentgenology,
Yanjun Chen, and
Liang Li, and
Nicole Le, and
Eric Y Chang, and
Wenhua Huang, and
Ya-Jun Ma
August 2011,
Magnetic resonance in medicine,
Yanjun Chen, and
Liang Li, and
Nicole Le, and
Eric Y Chang, and
Wenhua Huang, and
Ya-Jun Ma
March 2013,
Magnetic resonance in medicine,
Yanjun Chen, and
Liang Li, and
Nicole Le, and
Eric Y Chang, and
Wenhua Huang, and
Ya-Jun Ma
October 2015,
NMR in biomedicine,
Yanjun Chen, and
Liang Li, and
Nicole Le, and
Eric Y Chang, and
Wenhua Huang, and
Ya-Jun Ma
March 2004,
Magma (New York, N.Y.),
Yanjun Chen, and
Liang Li, and
Nicole Le, and
Eric Y Chang, and
Wenhua Huang, and
Ya-Jun Ma
September 1993,
European journal of radiology,
Yanjun Chen, and
Liang Li, and
Nicole Le, and
Eric Y Chang, and
Wenhua Huang, and
Ya-Jun Ma
February 2005,
Magnetic resonance in medicine,
Yanjun Chen, and
Liang Li, and
Nicole Le, and
Eric Y Chang, and
Wenhua Huang, and
Ya-Jun Ma
April 1993,
European journal of radiology,
Yanjun Chen, and
Liang Li, and
Nicole Le, and
Eric Y Chang, and
Wenhua Huang, and
Ya-Jun Ma
May 2013,
NMR in biomedicine,
