Biomaterial Database

Optimization of magnetization transfer contrast for EPI FLAIR brain imaging. 2022

Serdest Demir, and Bryan Clifford, and Wei-Ching Lo, and Azadeh Tabari, and Augusto Lio M Goncalves Filho, and Min Lang, and Stephen F Cauley, and Kawin Setsompop, and Berkin Bilgic, and Michael H Lev, and Pamela W Schaefer, and Otto Rapalino, and Susie Y Huang, and Tom Hilbert, and Thorsten Feiweier, and John Conklin

Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA.

To evaluate the impact of magnetization transfer (MT) on brain tissue contrast in turbo-spin-echo (TSE) and EPI fluid-attenuated inversion recovery (FLAIR) images, and to optimize an MT-prepared EPI FLAIR pulse sequence to match the tissue contrast of a clinical reference TSE FLAIR protocol. Five healthy volunteers underwent 3T brain MRI, including single slice TSE FLAIR, multi-slice TSE FLAIR, EPI FLAIR without MT-preparation, and MT-prepared EPI FLAIR with variations of the MT-preparation parameters, including number of preparation pulses, pulse amplitude, and resonance offset. Automated co-registration and gray matter (GM) versus white matter (WM) segmentation was performed using a T1-MPRAGE acquisition, and the GM versus WM signal intensity ratio (contrast ratio) was calculated for each FLAIR acquisition. Without MT preparation, EPI FLAIR showed poor tissue contrast (contrast ratio = 0.98), as did single slice TSE FLAIR. Multi-slice TSE FLAIR provided high tissue contrast (contrast ratio = 1.14). MT-prepared EPI FLAIR closely approximated the contrast of the multi-slice TSE FLAIR images for two combinations of the MT-preparation parameters (contrast ratio = 1.14). Optimized MT-prepared EPI FLAIR provided a 50% reduction in scan time compared to the reference TSE FLAIR acquisition. Optimized MT-prepared EPI FLAIR provides comparable brain tissue contrast to the multi-slice TSE FLAIR images used in clinical practice.

UI	MeSH Term	Description	Entries
D008279	Magnetic Resonance Imaging	Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.	Chemical Shift Imaging,MR Tomography,MRI Scans,MRI, Functional,Magnetic Resonance Image,Magnetic Resonance Imaging, Functional,Magnetization Transfer Contrast Imaging,NMR Imaging,NMR Tomography,Tomography, NMR,Tomography, Proton Spin,fMRI,Functional Magnetic Resonance Imaging,Imaging, Chemical Shift,Proton Spin Tomography,Spin Echo Imaging,Steady-State Free Precession MRI,Tomography, MR,Zeugmatography,Chemical Shift Imagings,Echo Imaging, Spin,Echo Imagings, Spin,Functional MRI,Functional MRIs,Image, Magnetic Resonance,Imaging, Magnetic Resonance,Imaging, NMR,Imaging, Spin Echo,Imagings, Chemical Shift,Imagings, Spin Echo,MRI Scan,MRIs, Functional,Magnetic Resonance Images,Resonance Image, Magnetic,Scan, MRI,Scans, MRI,Shift Imaging, Chemical,Shift Imagings, Chemical,Spin Echo Imagings,Steady State Free Precession MRI
D001921	Brain	The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.	Encephalon
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D017352	Echo-Planar Imaging	A type of MAGNETIC RESONANCE IMAGING that uses only one nuclear spin excitation per image and therefore can obtain images in a fraction of a second rather than the minutes required in traditional MRI techniques. It is used in a variety of medical and scientific applications.	MR Tomography, Echo-Planar,Magnetic Resonance Imaging, Echo-Planar,Echo-Planar MR Tomography,Echo-Planar Magnetic Resonance Imaging,Echoplanar Imaging,Echoplanar MR Tomography,Echoplanar Magnetic Resonance Imaging,MR Tomography, Echoplanar,Magnetic Resonance Imaging, Echoplanar,Echo Planar Imaging,Echo Planar MR Tomography,Echo Planar Magnetic Resonance Imaging,Echo-Planar Imagings,Echo-Planar MR Tomographies,Echoplanar Imagings,Echoplanar MR Tomographies,Imaging, Echo-Planar,Imaging, Echoplanar,Imagings, Echo-Planar,Imagings, Echoplanar,MR Tomographies, Echo-Planar,MR Tomographies, Echoplanar,MR Tomography, Echo Planar,Magnetic Resonance Imaging, Echo Planar,Tomographies, Echo-Planar MR,Tomographies, Echoplanar MR,Tomography, Echo-Planar MR,Tomography, Echoplanar MR
D059906	Neuroimaging	Non-invasive methods of visualizing the CENTRAL NERVOUS SYSTEM, especially the brain, by various imaging modalities.	Brain Imaging,Imaging, Brain
D066127	White Matter	The region of CENTRAL NERVOUS SYSTEM that appears lighter in color than the other type, GRAY MATTER. It mainly consists of MYELINATED NERVE FIBERS and contains few neuronal cell bodies or DENDRITES.	Cerebellar White Matter,Cerebellar White Matters,Matter, Cerebellar White,Matter, White,Matters, Cerebellar White,Matters, White,White Matter, Cerebellar,White Matters,White Matters, Cerebellar
D066128	Gray Matter	Region of CENTRAL NERVOUS SYSTEM that appears darker in color than the other type, WHITE MATTER. It is composed of neuronal CELL BODIES; NEUROPIL; GLIAL CELLS and CAPILLARIES but few MYELINATED NERVE FIBERS.	Cerebellar Gray Matter,Cerebellar Grey Matter,Grey Matter,Cerebellar Gray Matters,Cerebellar Grey Matters,Gray Matter, Cerebellar,Gray Matters,Gray Matters, Cerebellar,Grey Matter, Cerebellar,Grey Matters,Grey Matters, Cerebellar,Matter, Cerebellar Gray,Matter, Cerebellar Grey,Matter, Gray,Matter, Grey,Matters, Cerebellar Gray,Matters, Cerebellar Grey,Matters, Gray,Matters, Grey