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We evaluated the effects of pituitary dependent hormones on alpha 1-antitrypsin in male rats. Hepatic alpha 1-antitrypsin mRNA was measured by in vitro translation and by specific hybridization with a mouse cDNA alpha 1-antitrypsin probe. Hypophysectomy caused a 50-75% decrease in serum elastase inhibitory capacity (measuring functional alpha 1-antitrypsin) and hepatic alpha 1-antitrypsin mRNA content. In hypophysectomized animals, no increase in elastase inhibitory capacity or alpha 1-antitrypsin mRNA levels by translation was found when met-human growth hormone alone or corticosterone, dihydrotestosterone and thyroxine were given together. Growth hormone increased alpha 1-antitrypsin mRNA by hybridization to a small extent. Addition of growth hormone to the combination of corticosterone, dihydrotestosterone, and thyroxine increased serum elastase inhibitory capacity and alpha 1-antitrypsin mRNA. We conclude that growth hormone acts synergistically with the other pituitary dependent hormones to regulate serum and hepatic mRNA levels of alpha 1-antitrypsin.
S J Schwarzenberg, and
H L Sharp, and
S A Berry, and
R D Manthei, and
S Seelig
January 1986,
Medicina,
S J Schwarzenberg, and
H L Sharp, and
S A Berry, and
R D Manthei, and
S Seelig
May 1986,
The American journal of pathology,
S J Schwarzenberg, and
H L Sharp, and
S A Berry, and
R D Manthei, and
S Seelig
February 1986,
Revista espanola de las enfermedades del aparato digestivo,
S J Schwarzenberg, and
H L Sharp, and
S A Berry, and
R D Manthei, and
S Seelig
April 1989,
British journal of experimental pathology,
S J Schwarzenberg, and
H L Sharp, and
S A Berry, and
R D Manthei, and
S Seelig
April 1988,
British journal of experimental pathology,
S J Schwarzenberg, and
H L Sharp, and
S A Berry, and
R D Manthei, and
S Seelig
July 1968,
The New England journal of medicine,
S J Schwarzenberg, and
H L Sharp, and
S A Berry, and
R D Manthei, and
S Seelig
March 1972,
Chest,
S J Schwarzenberg, and
H L Sharp, and
S A Berry, and
R D Manthei, and
S Seelig
December 1988,
The Journal of the Association of Physicians of India,
S J Schwarzenberg, and
H L Sharp, and
S A Berry, and
R D Manthei, and
S Seelig
January 1976,
Revue medicale de la Suisse romande,
S J Schwarzenberg, and
H L Sharp, and
S A Berry, and
R D Manthei, and
S Seelig
July 1974,
American journal of clinical pathology,
