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Lewis rats with retinal S-antigen-induced uveitis were treated with the enzymatic antioxidants superoxide dismutase and catalase or with the hydroxyl radical scavenger dimethyl thiourea for one week. The enucleated eyes of these animals and of normal saline-treated control rats were studied for the presence of lipid peroxidation products in the retina; In addition, choroidal thickness was measured by morphometric analysis to determine the severity of choroidal inflammation. Control animals showed severe chorioretinal inflammation and presence of lipid peroxidation products. Intraocular inflammation was less severe and formation of conjugated dienes and malonaldehyde was significantly inhibited in animals treated with the enzyme antioxidants or dimethyl thiourea. These results suggest that free radicals generated during intraocular inflammation can lead to retinal damage by peroxidation of its lipid cell membranes.
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A Sevanian
October 1993,
Investigative ophthalmology & visual science,
N A Rao, and
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June 1992,
Current eye research,
N A Rao, and
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A Sevanian
January 1992,
Free radical biology & medicine,
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March 1983,
Biulleten' eksperimental'noi biologii i meditsiny,
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January 1994,
International ophthalmology,
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A Sevanian
May 1991,
Nippon Ganka Gakkai zasshi,
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Patologicheskaia fiziologiia i eksperimental'naia terapiia,
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January 1984,
Current eye research,
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January 1988,
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January 2002,
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