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Perylenequinone derivatives from the endolichenic fungus Phialocephala fortinii. 2023
Jintong Song, and
Fei Xie, and
Xiaoyi Luan, and
Ke Xu, and
Lilin Qian, and
Jinghui Lu, and
Wenqiang Chang, and
Xiaoning Wang, and
Hongxiang Lou
Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan, P.R. China.
Five undescribed perylenequinone derivatives (PQDs) phialocephalarins H - L (1 - 5), together with two known PQDs phialocephalarins A - B (6, 7) and one known spirobisnaphthalene palmarumycin P3 (8) were isolated from the endolichenic fungus Phialocephala fortinii. Their structures were elucidated on the basis of NMR and HRESIMS data as well as electronic circular dichroism (ECD) calculations. Compounds 1, 2, 4, and 6 - 8 were evaluated for cytotoxic activities against NCI-H460, NCI-H446, PC3, and EC109 cell lines. The results showed that compounds 1, 2, 6, and 8 showed cytotoxic activities against EC109 cells with IC50 values ranging from 24.5 to 33.3 μM.
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