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Pregnancy is a natural allograft and the mechanisms for its non-rejection are obscure. Depression of maternal cellular immunity was suggested as a possible explanation. Interleukin-2(IL-2) is a lymphokine release from OKT4+ lymphocyte. This factor has a crucial role in the proliferation and differentiation of T cell subsets, and controls functions associated with immune rejection mechanisms. We therefore examined the ability of lymphocytes from women in the 3 trimesters of pregnancy to produce IL-2 in culture. Mononuclear cells were cultured with PHA for 48 h. The IL-2-containing supernatant was added to and supported the proliferation of an IL-2 dependent T cell line. Proliferation of this line indicated the IL-2 content of the added supernatant. Using this assay, IL-2 production in all 3 trimesters of pregnancy was adequate and comparable to that of lymphocytes from non-pregnant women. These results suggest that the proposed defect in cellular immunity during pregnancy is not mediated by an inability of the lymphocytes to produce IL-2.
G J Hauser, and
A Lidor, and
V Zakuth, and
H Rosenberg, and
T Bino, and
M P David, and
Z Spirer
September 1985,
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G J Hauser, and
A Lidor, and
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H Rosenberg, and
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Z Spirer
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G J Hauser, and
A Lidor, and
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August 1991,
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G J Hauser, and
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G J Hauser, and
A Lidor, and
V Zakuth, and
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G J Hauser, and
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G J Hauser, and
A Lidor, and
V Zakuth, and
H Rosenberg, and
T Bino, and
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Z Spirer
September 1989,
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G J Hauser, and
A Lidor, and
V Zakuth, and
H Rosenberg, and
T Bino, and
M P David, and
Z Spirer
January 1989,
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G J Hauser, and
A Lidor, and
V Zakuth, and
H Rosenberg, and
T Bino, and
M P David, and
Z Spirer
August 1985,
European journal of cancer & clinical oncology,
