Biomaterial Database

Affinity, Specificity, and Cooperativity of DNA Binding by Bacterial Gene Regulatory Proteins. 2022

Jannette Carey

Chemistry Department, Princeton University, Princeton, NJ 08544, USA.

Nearly all of biology depends on interactions between molecules: proteins with small molecules, proteins with other proteins, nucleic acids with small molecules, and nucleic acids with proteins that regulate gene expression, our concern in this Special Issue. All those kinds of interactions, and others, constitute the vast majority of biology at the molecular level. An understanding of those interactions requires that we quantify them to learn how they interact: How strongly? With which partners? How-and how well-are different partners distinguished? This review addresses the evolution of our current understanding of the molecular origins of affinity and specificity in regulatory protein-DNA interactions, and suggests that both these properties can be modulated by cooperativity.

UI	MeSH Term	Description	Entries
D008954	Models, Biological	Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.	Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D011485	Protein Binding	The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.	Plasma Protein Binding Capacity,Binding, Protein
D004247	DNA	A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).	DNA, Double-Stranded,Deoxyribonucleic Acid,ds-DNA,DNA, Double Stranded,Double-Stranded DNA,ds DNA
D004268	DNA-Binding Proteins	Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.	DNA Helix Destabilizing Proteins,DNA-Binding Protein,Single-Stranded DNA Binding Proteins,DNA Binding Protein,DNA Single-Stranded Binding Protein,SS DNA BP,Single-Stranded DNA-Binding Protein,Binding Protein, DNA,DNA Binding Proteins,DNA Single Stranded Binding Protein,DNA-Binding Protein, Single-Stranded,Protein, DNA-Binding,Single Stranded DNA Binding Protein,Single Stranded DNA Binding Proteins
D005786	Gene Expression Regulation	Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.	Gene Action Regulation,Regulation of Gene Expression,Expression Regulation, Gene,Regulation, Gene Action,Regulation, Gene Expression
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000076662	Host Microbial Interactions	Interactions between a host and microbe or microbiota.	Host-Bacteria Interactions,Host-Microbe Interactions,Host-Microbial Interactions,Host-Virus Interactions,Microbe-Host Interactions,Microbial-Host Interactions,Microbiota-Host Interactions,Virus-Host Interactions,Bacteria Host Interactions,Bacterial-Host Interactions,Bacterium-Host Interactions,Host Bacteria Interactions,Host Microbe Interactions,Host Microbiota Interactions,Host Virus Interactions,Host-Fungal Interactions,Host-Microbial Interface,Microbe Host Interactions,Microbial Host Interactions,Microbiota Host Interactions,Viral-Host Interactions,Virus Host Interactions,Bacteria Host Interaction,Bacterial Host Interactions,Bacterial-Host Interaction,Bacterium Host Interactions,Bacterium-Host Interaction,Host Bacteria Interaction,Host Fungal Interactions,Host Microbe Interaction,Host Microbial Interaction,Host Microbial Interface,Host Microbiota Interaction,Host Virus Interaction,Host-Bacteria Interaction,Host-Fungal Interaction,Host-Microbe Interaction,Host-Microbial Interaction,Host-Microbial Interfaces,Host-Virus Interaction,Interaction, Host-Bacteria,Interaction, Host-Microbe,Interaction, Host-Microbial,Interaction, Host-Virus,Interaction, Microbe-Host,Interaction, Microbial-Host,Interaction, Microbiota-Host,Interaction, Virus-Host,Interactions, Host-Bacteria,Interactions, Host-Microbe,Interactions, Host-Microbial,Interactions, Host-Virus,Interactions, Microbe-Host,Interactions, Microbial-Host,Interactions, Microbiota-Host,Interactions, Virus-Host,Microbe Host Interaction,Microbe-Host Interaction,Microbial Host Interaction,Microbial-Host Interaction,Microbiota Host Interaction,Microbiota-Host Interaction,Viral Host Interactions,Viral-Host Interaction,Virus Host Interaction,Virus-Host Interaction
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001426	Bacterial Proteins	Proteins found in any species of bacterium.	Bacterial Gene Products,Bacterial Gene Proteins,Gene Products, Bacterial,Bacterial Gene Product,Bacterial Gene Protein,Bacterial Protein,Gene Product, Bacterial,Gene Protein, Bacterial,Gene Proteins, Bacterial,Protein, Bacterial,Proteins, Bacterial
D018407	Bacterial Physiological Phenomena	Physiological processes and properties of BACTERIA.	Bacterial Physiology,Bacterial Processes,Bacterial Physiological Concepts,Bacterial Physiological Phenomenon,Bacterial Process,Physiology, Bacterial,Bacterial Physiological Concept,Concept, Bacterial Physiological,Concepts, Bacterial Physiological,Phenomena, Bacterial Physiological,Phenomenon, Bacterial Physiological,Process, Bacterial,Processes, Bacterial