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An association of HLA-DR5 and goitrous autoimmune thyroiditis has been reported elsewhere (Farid et al., 1981; Weissel et al., 1980). Recently, the disease was found to be associated with HLA-DR4 in Newfoundlanders (Farid & Thompson, 1986). In order to find out whether different HLA associations with the disease may be found in different ethnic groups, we have now typed 68 patients with autoimmune goitrous thyroiditis from Eastern Hungary for HLA-A, -B, -C, and -DR antigens; 66 of these patients were also typed for IgG heavy-chain markers (Gm). A significant increase in DR3 (OR = 3.30) and a non-significant increase in DR4 (OR = 1.67) were found in the patients when compared with controls. The Gm3 allele, g, interacted with DR3 to enhance the risk for goitrous autoimmune thyroiditis. Hashimoto's disease may show different associations in different ethnic groups, and indeed within the same ethnic group, when newly diagnosed patients are typed several years apart.
V Stenszky, and
C Balázs, and
E Kraszits, and
F Juhasz, and
L Kozma, and
G Balázs, and
N R Farid
March 1981,
Tissue antigens,
V Stenszky, and
C Balázs, and
E Kraszits, and
F Juhasz, and
L Kozma, and
G Balázs, and
N R Farid
April 1986,
Molecular biology & medicine,
V Stenszky, and
C Balázs, and
E Kraszits, and
F Juhasz, and
L Kozma, and
G Balázs, and
N R Farid
January 1972,
Acta paediatrica Scandinavica,
V Stenszky, and
C Balázs, and
E Kraszits, and
F Juhasz, and
L Kozma, and
G Balázs, and
N R Farid
September 1996,
The Journal of experimental medicine,
V Stenszky, and
C Balázs, and
E Kraszits, and
F Juhasz, and
L Kozma, and
G Balázs, and
N R Farid
March 1979,
Clinics in endocrinology and metabolism,
V Stenszky, and
C Balázs, and
E Kraszits, and
F Juhasz, and
L Kozma, and
G Balázs, and
N R Farid
June 2005,
Journal of autoimmunity,
V Stenszky, and
C Balázs, and
E Kraszits, and
F Juhasz, and
L Kozma, and
G Balázs, and
N R Farid
June 2004,
Cellular immunology,
V Stenszky, and
C Balázs, and
E Kraszits, and
F Juhasz, and
L Kozma, and
G Balázs, and
N R Farid
October 1981,
Acta endocrinologica,
V Stenszky, and
C Balázs, and
E Kraszits, and
F Juhasz, and
L Kozma, and
G Balázs, and
N R Farid
July 2004,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
V Stenszky, and
C Balázs, and
E Kraszits, and
F Juhasz, and
L Kozma, and
G Balázs, and
N R Farid
January 1985,
Immunology letters,
