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There is ever increasing evidence that immune disturbances can play an essential role in the pathogenesis of progressive systemic sclerosis. However, there are still a great many controversial opinions and complex studies in this domain are few. Tests of lymphocyte blastic transformation and of leukocyte migration inhibition as well as E and EAC rosette tests were performed and the serum level of A, G and M immunoglobulins and complement were estimated in 13 patients with progressive systemic sclerosis. The increase of serum IgA, IgG and IgM and the decrease of early and delayed E rosette formation was observed in the patients as compared with the control group. The patients also presented increase spontaneous and PHA induced lymphocyte blastic transformation. The results support the hypothesis of the role played by immune disturbances in the pathogenesis of progressive systemic sclerosis.
S Sierakowski, and
K Bernacka
March 1972,
Annals of the rheumatic diseases,
S Sierakowski, and
K Bernacka
February 1983,
Vrachebnoe delo,
S Sierakowski, and
K Bernacka
January 1982,
Terapevticheskii arkhiv,
S Sierakowski, and
K Bernacka
January 1975,
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S Sierakowski, and
K Bernacka
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S Sierakowski, and
K Bernacka
July 1982,
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S Sierakowski, and
K Bernacka
January 1985,
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S Sierakowski, and
K Bernacka
March 1975,
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S Sierakowski, and
K Bernacka
January 1978,
Acta medica Scandinavica,
