Biomaterial Database

Propofol or methohexitone for induction of anaesthesia for minor gynaecological procedures. 1987

T P Lombard, and J L Couper

Department of Anaesthesiology, Medical University of Southern Africa.

A new anaesthetic induction agent, propofol (Diprivan; Stuart), was used to induce anaesthesia in 16 healthy patients scheduled for minor gynaecological surgery. The findings were then compared with those in a subsequent group of 16 patients who received methohexitone for induction of anaesthesia. Halothane was used to maintain anaesthesia in all cases. Quality of induction, side-effects, cardiovascular indices, wake-up times and presence or absence of recall were recorded. Propofol caused fewer side-effects on induction and emergence and less change in heart rate than methohexitone, and patients were more clear-headed on awakening. Our findings indicate that propofol is a promising agent for induction of anaesthesia for day-case surgery.

UI	MeSH Term	Description	Entries
D008723	Methohexital	An intravenous anesthetic with a short duration of action that may be used for induction of anesthesia.	Methohexitone,Brevimytal Natrium,Brevital,Brietal,Brietal-Sodium,Methohexital Sodium,Methohexital, Monosodium Salt,Brietal Sodium,Monosodium Salt Methohexital,Natrium, Brevimytal,Sodium, Methohexital
D010636	Phenols	Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.
D001794	Blood Pressure	PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.	Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D004341	Drug Evaluation	Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.	Evaluation Studies, Drug,Drug Evaluation Studies,Drug Evaluation Study,Drug Evaluations,Evaluation Study, Drug,Evaluation, Drug,Evaluations, Drug,Studies, Drug Evaluation,Study, Drug Evaluation
D005260	Female		Females
D005831	Genital Diseases, Female	Pathological processes involving the female reproductive tract (GENITALIA, FEMALE).	Gynecologic Diseases,Female Genital Diseases,Diseases, Female Genital,Diseases, Gynecologic,Female Genital Disease,Genital Disease, Female,Gynecologic Disease
D006339	Heart Rate	The number of times the HEART VENTRICLES contract per unit of time, usually per minute.	Cardiac Rate,Chronotropism, Cardiac,Heart Rate Control,Heartbeat,Pulse Rate,Cardiac Chronotropy,Cardiac Chronotropism,Cardiac Rates,Chronotropy, Cardiac,Control, Heart Rate,Heart Rates,Heartbeats,Pulse Rates,Rate Control, Heart,Rate, Cardiac,Rate, Heart,Rate, Pulse
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000777	Anesthetics	Agents capable of inducing a total or partial loss of sensation, especially tactile sensation and pain. They may act to induce general ANESTHESIA, in which an unconscious state is achieved, or may act locally to induce numbness or lack of sensation at a targeted site.	Anesthetic,Anesthetic Agents,Anesthetic Drugs,Anesthetic Effect,Anesthetic Effects,Agents, Anesthetic,Drugs, Anesthetic,Effect, Anesthetic,Effects, Anesthetic
D013511	Minor Surgical Procedures	Surgery for problems and injuries that are of relatively slight extent, and with a low risk for life threatening complications.	Minor Surgery,Surgical Procedures, Minor,Minor Surgical Procedure,Procedure, Minor Surgical,Procedures, Minor Surgical,Surgery, Minor,Surgical Procedure, Minor,Minor Surgeries,Surgeries, Minor