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Bioactive materials is defined as substances that elicit special chemical bonding at the interface between tissues and the material. In recent years, more and more bioactive materials have emerged in endodontic treatment. The present article introduces the definition, classification and application of bioactive materials in endodontics. Combined with evidence-based medicine and bioactive materials, optimum treatment recommendations for various endodontic diseases are provided and the development trend of bioactive materials in endodontics is also discussed.
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