BIOMAT Database Logo BIOMAT Database Logo

[Carminomycin study in breast cancer]. 1978

M R Lichinitser, and I V Assekritova, and V A Gorbunova, and S A Arseriĭ, and Kh M Vaarik

Karminomycin was used for the treatment of cases with disseminated cancer of the mammary gland in doses of 5 mg/m2 of the body surface intravenously every day for 5 days (15 patients) or 6 mg/m2 twice a week for 2-3 weeks (30 patients). Partial remission or diminution of the tumor size at least by 50 per cent was observed in 26 and 17 per cent of the patients respectively. The remission duration was from 2 to 6 months. With the use of the shortperiod scheme the frequency of the direct side reactions increased. Leucopenia as a side effect was registered in 100 and 40 per cent of the patients and thrombocytopenia was registered in 18 and 3 per cent of the cases respectively.

UI MeSH Term Description Entries
D007970 Leukopenia A decrease in the number of LEUKOCYTES in a blood sample below the normal range (LEUKOCYTE COUNT less than 4000). Leukocytopenia,Leukocytopenias,Leukopenias
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D001943 Breast Neoplasms Tumors or cancer of the human BREAST. Breast Cancer,Breast Tumors,Cancer of Breast,Breast Carcinoma,Cancer of the Breast,Human Mammary Carcinoma,Malignant Neoplasm of Breast,Malignant Tumor of Breast,Mammary Cancer,Mammary Carcinoma, Human,Mammary Neoplasm, Human,Mammary Neoplasms, Human,Neoplasms, Breast,Tumors, Breast,Breast Carcinomas,Breast Malignant Neoplasm,Breast Malignant Neoplasms,Breast Malignant Tumor,Breast Malignant Tumors,Breast Neoplasm,Breast Tumor,Cancer, Breast,Cancer, Mammary,Cancers, Mammary,Carcinoma, Breast,Carcinoma, Human Mammary,Carcinomas, Breast,Carcinomas, Human Mammary,Human Mammary Carcinomas,Human Mammary Neoplasm,Human Mammary Neoplasms,Mammary Cancers,Mammary Carcinomas, Human,Neoplasm, Breast,Neoplasm, Human Mammary,Neoplasms, Human Mammary,Tumor, Breast
D002360 Carubicin A very toxic anthracycline-type antineoplastic related to DAUNORUBICIN, obtained from Actinomadura carminata. Carminomycin,Karminomycin,Carminomicin,Carminomycin I,Carminomycin II,Carminomycin III,Carubicin Hydrochloride,Demethyldaunomycin,Demethyldaunorubicin,Karminomicin,NSC-180,024,NSC-180024,Rubeomycin A,Rubeomycin A1,Hydrochloride, Carubicin,NSC 180,024,NSC 180024,NSC180,024,NSC180024
D002986 Clinical Trials as Topic Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries. Clinical Trial as Topic
D004341 Drug Evaluation Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals. Evaluation Studies, Drug,Drug Evaluation Studies,Drug Evaluation Study,Drug Evaluations,Evaluation Study, Drug,Evaluation, Drug,Evaluations, Drug,Studies, Drug Evaluation,Study, Drug Evaluation
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000903 Antibiotics, Antineoplastic Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms. Antineoplastic Antibiotics,Cytotoxic Antibiotics,Antibiotics, Cytotoxic
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor

Related Publications

M R Lichinitser, and I V Assekritova, and V A Gorbunova, and S A Arseriĭ, and Kh M Vaarik
Carminomycin versus doxorubicin in advanced breast cancer, a randomized phase II study of the E.O.R.T.C. Breast Cancer Cooperative Group.
May 1986, European journal of cancer & clinical oncology,
M R Lichinitser, and I V Assekritova, and V A Gorbunova, and S A Arseriĭ, and Kh M Vaarik
Carminomycin. A new anthracycline analog in the treatment of advanced breast cancer.
January 1984, Cancer,
M R Lichinitser, and I V Assekritova, and V A Gorbunova, and S A Arseriĭ, and Kh M Vaarik
[Results of a clinical study of carminomycin in primary disseminated forms, recurrences and metastases of breast cancer].
January 1983, Voprosy onkologii,
M R Lichinitser, and I V Assekritova, and V A Gorbunova, and S A Arseriĭ, and Kh M Vaarik
Randomized phase II trial of carminomycin versus 4'-epidoxorubicin in advanced breast cancer.
April 1984, Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
M R Lichinitser, and I V Assekritova, and V A Gorbunova, and S A Arseriĭ, and Kh M Vaarik
[Use of carminomycin in bladder cancer].
January 1979, Voprosy onkologii,
M R Lichinitser, and I V Assekritova, and V A Gorbunova, and S A Arseriĭ, and Kh M Vaarik
Clinical controlled trial in advanced breast cancer: CMFV (cyclophosphamide, methotrexate, fluorouracil, vincristine) verus CD (carminomycin, dibromodulcitol).
January 1982, Neoplasma,
M R Lichinitser, and I V Assekritova, and V A Gorbunova, and S A Arseriĭ, and Kh M Vaarik
Electrochemical study of carminomycin at solid electrodes.
December 1988, Talanta,
M R Lichinitser, and I V Assekritova, and V A Gorbunova, and S A Arseriĭ, and Kh M Vaarik
Carminomycin (NSC-180024): a phase I study.
December 1980, European journal of cancer,
M R Lichinitser, and I V Assekritova, and V A Gorbunova, and S A Arseriĭ, and Kh M Vaarik
[Study of the toxicity of carminomycin 13-cyclohexylidenhydrazone].
February 1983, Antibiotiki,
M R Lichinitser, and I V Assekritova, and V A Gorbunova, and S A Arseriĭ, and Kh M Vaarik
Antitumor antibiotic carminomycin.
January 1980, Zeitschrift fur allgemeine Mikrobiologie,
Copied contents to your clipboard!