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The antineoplastic drugs Vincristine (VCR) and Vinblastine (VBL) were tested for their effects on Concanavalin A induced Interleukin-2 (IL-2) release by rat splenocytes. Both drugs were found to inhibit IL-2 release in vitro. This effect was noted at doses of 10 ng/ml and 100 ng/ml in case of VBL and at doses of 1 ng/ml, 10 ng/ml and 100 ng/ml with VCR. The in vivo effect of these drugs was studied by injection into rats three days before culture of splenocytes. This also resulted in inhibition of IL-2 release. The effect was manifested with VCR at doses of 0.1 mg/kg bw and 0.5 mg/kg bw and with VBL at 2 mg/kg bw. These drugs were also tested for their effect on Interleukin-1 (IL-1) release by lipopolysaccharide (LPS) stimulated rat peritoneal exudate cells (PEC's) in vitro. No modulation of the production of IL-1 was seen.
K Ahmed, and
T A Abdul Hamied, and
J L Turk
March 1969,
Lancet (London, England),
K Ahmed, and
T A Abdul Hamied, and
J L Turk
December 1977,
Deutsche medizinische Wochenschrift (1946),
K Ahmed, and
T A Abdul Hamied, and
J L Turk
September 1976,
The New England journal of medicine,
K Ahmed, and
T A Abdul Hamied, and
J L Turk
November 1963,
Nature,
K Ahmed, and
T A Abdul Hamied, and
J L Turk
April 1977,
British journal of clinical pharmacology,
K Ahmed, and
T A Abdul Hamied, and
J L Turk
September 1982,
Cancer research,
K Ahmed, and
T A Abdul Hamied, and
J L Turk
January 1972,
Timarit Hjukrunarfelags Islands,
K Ahmed, and
T A Abdul Hamied, and
J L Turk
January 1970,
Neoplasma,
K Ahmed, and
T A Abdul Hamied, and
J L Turk
April 1972,
Documenta ophthalmologica. Advances in ophthalmology,
K Ahmed, and
T A Abdul Hamied, and
J L Turk
January 1968,
Il Cancro,
