BIOMAT Database Logo BIOMAT Database Logo

Idiotypic analysis of the influenza virus-specific human B cell repertoire. 1987

N H Sigal, and M Chan, and M A Reale, and T Moran, and J L Schulman, and C A Bona
Department of Immunology Research, Merck Sharp & Dohme Research Laboratories, Rahway, N.J.

UI MeSH Term Description Entries
D007130 Immunoglobulin Idiotypes Unique genetically-controlled determinants present on ANTIBODIES whose specificity is limited to a single group of proteins (e.g., another antibody molecule or an individual myeloma protein). The idiotype appears to represent the antigenicity of the antigen-binding site of the antibody and to be genetically codetermined with it. The idiotypic determinants have been precisely located to the IMMUNOGLOBULIN VARIABLE REGION of both immunoglobin polypeptide chains. Idiotypes, Immunoglobulin,Ig Idiotypes,Idiotype, Ig,Idiotype, Immunoglobulin,Idiotypes, Ig,Ig Idiotype,Immunoglobulin Idiotype
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009980 Influenza A virus The type species of the genus ALPHAINFLUENZAVIRUS that causes influenza and other diseases in humans and animals. Antigenic variation occurs frequently between strains, allowing classification into subtypes and variants. Transmission is usually by aerosol (human and most non-aquatic hosts) or waterborne (ducks). Infected birds shed the virus in their saliva, nasal secretions, and feces. Alphainfluenzavirus influenzae,Avian Orthomyxovirus Type A,FLUAV,Fowl Plague Virus,Human Influenza A Virus,Influenza Virus Type A,Influenza Viruses Type A,Myxovirus influenzae-A hominis,Myxovirus influenzae-A suis,Myxovirus pestis galli,Orthomyxovirus Type A,Orthomyxovirus Type A, Avian,Orthomyxovirus Type A, Human,Orthomyxovirus Type A, Porcine,Pestis galli Myxovirus,Fowl Plague Viruses,Influenza A viruses,Myxovirus influenzae A hominis,Myxovirus influenzae A suis,Myxovirus, Pestis galli,Myxoviruses, Pestis galli,Pestis galli Myxoviruses,Plague Virus, Fowl,Virus, Fowl Plague
D009981 Influenza B virus Species of the genus BETAINFLUENZAVIRUS that cause HUMAN INFLUENZA and other diseases primarily in humans. Antigenic variation is less extensive than in type A viruses (INFLUENZA A VIRUS) and consequently there is no basis for distinct subtypes or variants. Epidemics are less likely than with INFLUENZA A VIRUS and there have been no pandemics. Previously only found in humans, Influenza B virus has been isolated from seals which may constitute the animal reservoir from which humans are exposed. Betainfluenzavirus influenzae,FLUBV,Human Influenza B Virus,Influenza Viruses Type B,Influenza virus type B,Orthomyxoviruses Type B,Influenza B viruses
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D000911 Antibodies, Monoclonal Antibodies produced by a single clone of cells. Monoclonal Antibodies,Monoclonal Antibody,Antibody, Monoclonal
D000914 Antibodies, Viral Immunoglobulins produced in response to VIRAL ANTIGENS. Viral Antibodies
D000917 Antibody Formation The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS. Antibody Production,Antibody Response,Antibody Responses,Formation, Antibody,Production, Antibody,Response, Antibody,Responses, Antibody

Related Publications

N H Sigal, and M Chan, and M A Reale, and T Moran, and J L Schulman, and C A Bona
Influenza Virus-Specific Human Antibody Repertoire Studies.
January 2019, Journal of immunology (Baltimore, Md. : 1950),
N H Sigal, and M Chan, and M A Reale, and T Moran, and J L Schulman, and C A Bona
Idiotypic regulation of development of the B-cell repertoire.
May 1992, Annals of the New York Academy of Sciences,
N H Sigal, and M Chan, and M A Reale, and T Moran, and J L Schulman, and C A Bona
Recognition of influenza virus-infected B-cell lines by human influenza virus-specific CTL.
February 1988, Cellular immunology,
N H Sigal, and M Chan, and M A Reale, and T Moran, and J L Schulman, and C A Bona
Heterogeneity of the human phosphocholine-specific B cell repertoire.
March 1984, Journal of immunology (Baltimore, Md. : 1950),
N H Sigal, and M Chan, and M A Reale, and T Moran, and J L Schulman, and C A Bona
The role of idiotypic interactions and B-cell subsets in development of the B-cell repertoire.
January 1989, Cold Spring Harbor symposia on quantitative biology,
N H Sigal, and M Chan, and M A Reale, and T Moran, and J L Schulman, and C A Bona
The diversity of the influenza-specific primary B-cell repertoire in BALB/c mice.
March 1978, The Journal of experimental medicine,
N H Sigal, and M Chan, and M A Reale, and T Moran, and J L Schulman, and C A Bona
Host ethnicity and virus genotype shape the hepatitis B virus-specific T-cell repertoire.
November 2008, Journal of virology,
N H Sigal, and M Chan, and M A Reale, and T Moran, and J L Schulman, and C A Bona
Polyclonal B-cell activation by influenza A/Texas virus-specific human T-cell clones.
January 1987, Annales de l'Institut Pasteur. Immunology,
N H Sigal, and M Chan, and M A Reale, and T Moran, and J L Schulman, and C A Bona
B cell repertoire diversity to PR8 influenza virus does not decrease with age.
November 1984, Journal of immunology (Baltimore, Md. : 1950),
N H Sigal, and M Chan, and M A Reale, and T Moran, and J L Schulman, and C A Bona
Longitudinal analysis of the peripheral B cell repertoire reveals unique effects of immunization with a new influenza virus strain.
November 2015, Genome medicine,
Copied contents to your clipboard!