Biodistribution of methotrexate-monoclonal antibody conjugates and complexes: experimental and clinical studies. 1987

M V Pimm, and J A Clegg, and J E Caten, and K D Ballantyne, and A C Perkins, and M C Garnett, and R W Baldwin
Cancer Research Campaign Laboratories, University of Nottingham, U.K.

UI MeSH Term Description Entries
D008727 Methotrexate An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA. Amethopterin,Methotrexate Hydrate,Methotrexate Sodium,Methotrexate, (D)-Isomer,Methotrexate, (DL)-Isomer,Methotrexate, Dicesium Salt,Methotrexate, Disodium Salt,Methotrexate, Sodium Salt,Mexate,Dicesium Salt Methotrexate,Hydrate, Methotrexate,Sodium, Methotrexate
D009369 Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms. Benign Neoplasm,Cancer,Malignant Neoplasm,Tumor,Tumors,Benign Neoplasms,Malignancy,Malignant Neoplasms,Neoplasia,Neoplasm,Neoplasms, Benign,Cancers,Malignancies,Neoplasias,Neoplasm, Benign,Neoplasm, Malignant,Neoplasms, Malignant
D009374 Neoplasms, Experimental Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms. Experimental Neoplasms,Experimental Neoplasm,Neoplasm, Experimental
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000911 Antibodies, Monoclonal Antibodies produced by a single clone of cells. Monoclonal Antibodies,Monoclonal Antibody,Antibody, Monoclonal
D000922 Immunotoxins Semisynthetic conjugates of various toxic molecules, including RADIOACTIVE ISOTOPES and bacterial or plant toxins, with specific immune substances such as IMMUNOGLOBULINS; MONOCLONAL ANTIBODIES; and ANTIGENS. The antitumor or antiviral immune substance carries the toxin to the tumor or infected cell where the toxin exerts its poisonous effect. Affinotoxin,Antibody-Toxin Conjugate,Antibody-Toxin Conjugates,Antibody-Toxin Hybrid,Antibody-Toxin Hybrids,Chimeric Toxins,Cytotoxin-Antibody Conjugate,Cytotoxin-Antibody Conjugates,Monoclonal Antibody-Toxin Conjugate,Targeted Toxin,Targeted Toxins,Toxin Carriers,Toxin Conjugates,Toxin-Antibody Conjugate,Toxin-Antibody Conjugates,Toxin-Antibody Hybrid,Toxin-Antibody Hybrids,Toxins, Chimeric,Toxins, Targeted,Affinotoxins,Chimeric Toxin,Immunotoxin,Monoclonal Antibody-Toxin Conjugates,Toxin Carrier,Toxin Conjugate,Antibody Toxin Conjugate,Antibody Toxin Conjugates,Antibody Toxin Hybrid,Antibody Toxin Hybrids,Antibody-Toxin Conjugate, Monoclonal,Antibody-Toxin Conjugates, Monoclonal,Carrier, Toxin,Carriers, Toxin,Conjugate, Antibody-Toxin,Conjugate, Cytotoxin-Antibody,Conjugate, Monoclonal Antibody-Toxin,Conjugate, Toxin,Conjugate, Toxin-Antibody,Conjugates, Antibody-Toxin,Conjugates, Cytotoxin-Antibody,Conjugates, Monoclonal Antibody-Toxin,Conjugates, Toxin,Conjugates, Toxin-Antibody,Cytotoxin Antibody Conjugate,Cytotoxin Antibody Conjugates,Hybrid, Antibody-Toxin,Hybrid, Toxin-Antibody,Hybrids, Antibody-Toxin,Hybrids, Toxin-Antibody,Monoclonal Antibody Toxin Conjugate,Monoclonal Antibody Toxin Conjugates,Toxin Antibody Conjugate,Toxin Antibody Conjugates,Toxin Antibody Hybrid,Toxin Antibody Hybrids,Toxin, Chimeric,Toxin, Targeted
D014018 Tissue Distribution Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios. Distribution, Tissue,Distributions, Tissue,Tissue Distributions
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus

Related Publications

M V Pimm, and J A Clegg, and J E Caten, and K D Ballantyne, and A C Perkins, and M C Garnett, and R W Baldwin
August 1985, Journal of the National Cancer Institute,
M V Pimm, and J A Clegg, and J E Caten, and K D Ballantyne, and A C Perkins, and M C Garnett, and R W Baldwin
December 1999, Photochemistry and photobiology,
M V Pimm, and J A Clegg, and J E Caten, and K D Ballantyne, and A C Perkins, and M C Garnett, and R W Baldwin
April 1987, Immunology and cell biology,
M V Pimm, and J A Clegg, and J E Caten, and K D Ballantyne, and A C Perkins, and M C Garnett, and R W Baldwin
December 1987, Immunology and cell biology,
M V Pimm, and J A Clegg, and J E Caten, and K D Ballantyne, and A C Perkins, and M C Garnett, and R W Baldwin
January 1987, NCI monographs : a publication of the National Cancer Institute,
M V Pimm, and J A Clegg, and J E Caten, and K D Ballantyne, and A C Perkins, and M C Garnett, and R W Baldwin
December 1988, Zhonghua yi xue za zhi = Chinese medical journal; Free China ed,
M V Pimm, and J A Clegg, and J E Caten, and K D Ballantyne, and A C Perkins, and M C Garnett, and R W Baldwin
October 1994, Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae,
M V Pimm, and J A Clegg, and J E Caten, and K D Ballantyne, and A C Perkins, and M C Garnett, and R W Baldwin
January 1985, International journal of nuclear medicine and biology,
M V Pimm, and J A Clegg, and J E Caten, and K D Ballantyne, and A C Perkins, and M C Garnett, and R W Baldwin
August 1993, Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae,
M V Pimm, and J A Clegg, and J E Caten, and K D Ballantyne, and A C Perkins, and M C Garnett, and R W Baldwin
January 1989, Cancer immunology, immunotherapy : CII,
Copied contents to your clipboard!