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We have treated 128 postmenopausal women with advanced breast cancer with 4-hydroxyandrostenedione. Of these, 118 were assessable for toxicity and 100 for response to treatment. Response to therapy was seen in 34% of patients and stabilization of disease in 12 patients. Three dose regimens were used (500 mg intramuscularly weekly; 250 mg intramuscularly every 2 weeks; and 500 mg orally daily). There was no difference in response in these three groups. Side effects were minimal and local reaction to injected drug was seen in 13% of patients. The sole severe side effect observed was neutropenia which was transient and reversible on discontinuing therapy. 4-Hydroxyandrostenedione is an effective nontoxic agent in the treatment of breast cancer.
R C Coombes, and
P E Goss, and
M Dowsett, and
G Hutchinson, and
D Cunningham, and
M Jarman, and
A M Brodie
September 1992,
The Journal of steroid biochemistry and molecular biology,
R C Coombes, and
P E Goss, and
M Dowsett, and
G Hutchinson, and
D Cunningham, and
M Jarman, and
A M Brodie
January 1990,
Cancer chemotherapy and pharmacology,
R C Coombes, and
P E Goss, and
M Dowsett, and
G Hutchinson, and
D Cunningham, and
M Jarman, and
A M Brodie
January 1992,
European journal of cancer (Oxford, England : 1990),
R C Coombes, and
P E Goss, and
M Dowsett, and
G Hutchinson, and
D Cunningham, and
M Jarman, and
A M Brodie
May 1990,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
R C Coombes, and
P E Goss, and
M Dowsett, and
G Hutchinson, and
D Cunningham, and
M Jarman, and
A M Brodie
April 1993,
Cancer treatment reviews,
R C Coombes, and
P E Goss, and
M Dowsett, and
G Hutchinson, and
D Cunningham, and
M Jarman, and
A M Brodie
August 1993,
British journal of cancer,
R C Coombes, and
P E Goss, and
M Dowsett, and
G Hutchinson, and
D Cunningham, and
M Jarman, and
A M Brodie
January 1987,
Cancer chemotherapy and pharmacology,
R C Coombes, and
P E Goss, and
M Dowsett, and
G Hutchinson, and
D Cunningham, and
M Jarman, and
A M Brodie
March 1989,
Cancer research,
R C Coombes, and
P E Goss, and
M Dowsett, and
G Hutchinson, and
D Cunningham, and
M Jarman, and
A M Brodie
January 1983,
European journal of cancer & clinical oncology,
R C Coombes, and
P E Goss, and
M Dowsett, and
G Hutchinson, and
D Cunningham, and
M Jarman, and
A M Brodie
January 1992,
Breast cancer research and treatment,
