The Effect of Long-Lasting Swimming on Rats Skeletal Muscles Energy Metabolism after Nine Days of Dexamethasone Treatment. 2022

Damian Jozef Flis, and Emilia Gabriela Bialobrodzka, and Ewa Aleksandra Rodziewicz-Flis, and Zbigniew Jost, and Andzelika Borkowska, and Wieslaw Ziolkowski, and Jan Jacek Kaczor
Department of Pharmaceutical Pathophysiology, Faculty of Pharmacy, Medical University of Gdansk, Dębinki 7 Street, 80-211 Gdansk, Poland.

This study investigates the effect of Dexamethasone (Dex) treatment on blood and skeletal muscle metabolites level and skeletal muscle activity of enzymes related to energy metabolism after long-duration swimming. To evaluate whether Dex treatment, swimming, and combining these factors act on analyzed data, rats were randomly divided into four groups: saline treatment non-exercise and exercise and Dex treatment non-exercised and exercised. Animals in both exercised groups underwent long-lasting swimming. The concentration of lipids metabolites, glucose, and lactate were measured in skeletal muscles and blood according to standard colorimetric and fluorimetric methods. Also, activities of enzymes related to aerobic and anaerobic metabolism were measured in skeletal muscles. The results indicated that Dex treatment induced body mass loss and increased lipid metabolites in the rats' blood but did not alter these changes in skeletal muscles. Interestingly, prolonged swimming applied after 9 days of Dex treatment significantly intensified changes induced by Dex; however, there was no difference in skeletal muscle enzymatic activities. This study shows for the first time the cumulative effect of exercise and Dex on selected elements of lipid metabolism, which seems to be essential for the patient's health due to the common use of glucocorticoids like Dex.

UI MeSH Term Description Entries
D008297 Male Males
D008928 Mitochondria Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed) Mitochondrial Contraction,Mitochondrion,Contraction, Mitochondrial,Contractions, Mitochondrial,Mitochondrial Contractions
D008954 Models, Biological Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment. Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D010805 Physical Conditioning, Animal Diet modification and physical exercise to improve the ability of animals to perform physical activities. Animal Physical Conditioning,Animal Physical Conditionings,Conditioning, Animal Physical,Conditionings, Animal Physical,Physical Conditionings, Animal
D003907 Dexamethasone An anti-inflammatory 9-fluoro-glucocorticoid. Hexadecadrol,Decaject,Decaject-L.A.,Decameth,Decaspray,Dexasone,Dexpak,Hexadrol,Maxidex,Methylfluorprednisolone,Millicorten,Oradexon,Decaject L.A.
D004734 Energy Metabolism The chemical reactions involved in the production and utilization of various forms of energy in cells. Bioenergetics,Energy Expenditure,Bioenergetic,Energy Expenditures,Energy Metabolisms,Expenditure, Energy,Expenditures, Energy,Metabolism, Energy,Metabolisms, Energy
D005947 Glucose A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement. Dextrose,Anhydrous Dextrose,D-Glucose,Glucose Monohydrate,Glucose, (DL)-Isomer,Glucose, (alpha-D)-Isomer,Glucose, (beta-D)-Isomer,D Glucose,Dextrose, Anhydrous,Monohydrate, Glucose
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D013312 Stress, Physiological The unfavorable effect of environmental factors (stressors) on the physiological functions of an organism. Prolonged unresolved physiological stress can affect HOMEOSTASIS of the organism, and may lead to damaging or pathological conditions. Biotic Stress,Metabolic Stress,Physiological Stress,Abiotic Stress,Abiotic Stress Reaction,Abiotic Stress Response,Biological Stress,Metabolic Stress Response,Physiological Stress Reaction,Physiological Stress Reactivity,Physiological Stress Response,Abiotic Stress Reactions,Abiotic Stress Responses,Abiotic Stresses,Biological Stresses,Biotic Stresses,Metabolic Stress Responses,Metabolic Stresses,Physiological Stress Reactions,Physiological Stress Responses,Physiological Stresses,Reaction, Abiotic Stress,Reactions, Abiotic Stress,Response, Abiotic Stress,Response, Metabolic Stress,Stress Reaction, Physiological,Stress Response, Metabolic,Stress Response, Physiological,Stress, Abiotic,Stress, Biological,Stress, Biotic,Stress, Metabolic
D013550 Swimming An activity in which the body is propelled through water by specific movement of the arms and/or the legs. Swimming as propulsion through water by the movement of limbs, tail, or fins of animals is often studied as a form of PHYSICAL EXERTION or endurance.

Related Publications

Damian Jozef Flis, and Emilia Gabriela Bialobrodzka, and Ewa Aleksandra Rodziewicz-Flis, and Zbigniew Jost, and Andzelika Borkowska, and Wieslaw Ziolkowski, and Jan Jacek Kaczor
January 1973, Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie,
Damian Jozef Flis, and Emilia Gabriela Bialobrodzka, and Ewa Aleksandra Rodziewicz-Flis, and Zbigniew Jost, and Andzelika Borkowska, and Wieslaw Ziolkowski, and Jan Jacek Kaczor
February 2001, Scandinavian journal of medicine & science in sports,
Damian Jozef Flis, and Emilia Gabriela Bialobrodzka, and Ewa Aleksandra Rodziewicz-Flis, and Zbigniew Jost, and Andzelika Borkowska, and Wieslaw Ziolkowski, and Jan Jacek Kaczor
April 2024, International journal of molecular sciences,
Damian Jozef Flis, and Emilia Gabriela Bialobrodzka, and Ewa Aleksandra Rodziewicz-Flis, and Zbigniew Jost, and Andzelika Borkowska, and Wieslaw Ziolkowski, and Jan Jacek Kaczor
January 1973, Patologicheskaia fiziologiia i eksperimental'naia terapiia,
Damian Jozef Flis, and Emilia Gabriela Bialobrodzka, and Ewa Aleksandra Rodziewicz-Flis, and Zbigniew Jost, and Andzelika Borkowska, and Wieslaw Ziolkowski, and Jan Jacek Kaczor
January 1978, Patologicheskaia fiziologiia i eksperimental'naia terapiia,
Damian Jozef Flis, and Emilia Gabriela Bialobrodzka, and Ewa Aleksandra Rodziewicz-Flis, and Zbigniew Jost, and Andzelika Borkowska, and Wieslaw Ziolkowski, and Jan Jacek Kaczor
January 1976, Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
Damian Jozef Flis, and Emilia Gabriela Bialobrodzka, and Ewa Aleksandra Rodziewicz-Flis, and Zbigniew Jost, and Andzelika Borkowska, and Wieslaw Ziolkowski, and Jan Jacek Kaczor
September 2001, Metabolism: clinical and experimental,
Damian Jozef Flis, and Emilia Gabriela Bialobrodzka, and Ewa Aleksandra Rodziewicz-Flis, and Zbigniew Jost, and Andzelika Borkowska, and Wieslaw Ziolkowski, and Jan Jacek Kaczor
April 1977, Chirurgisches Forum fur experimentelle und klinische Forschung,
Damian Jozef Flis, and Emilia Gabriela Bialobrodzka, and Ewa Aleksandra Rodziewicz-Flis, and Zbigniew Jost, and Andzelika Borkowska, and Wieslaw Ziolkowski, and Jan Jacek Kaczor
May 2017, BMC genomics,
Damian Jozef Flis, and Emilia Gabriela Bialobrodzka, and Ewa Aleksandra Rodziewicz-Flis, and Zbigniew Jost, and Andzelika Borkowska, and Wieslaw Ziolkowski, and Jan Jacek Kaczor
December 1995, Doklady Akademii nauk,
Copied contents to your clipboard!