Biomaterial Database

Treatment of symptomatic intestinal amoebiasis with tinidazole. 1978

E G Garcia

Tinidazole was given in a single dose of 2g a day for 2 days to 17 adults, and in a single dose of 50mg/kg bodyweight daily for 3 days to 4 children, with symptomatic, but not severe, intestinal amoebiasis. All 21 patients showed clinical improvement but only 20 (95%) were parasitologically cured as evinced by failure to demonstrate Entamoeba histolytica in 3 stool samples collected on the 4th, 15th and 22nd day after treatment. Two subjects had mild nausea within a few hours of taking the first dose, while 8 had constipation of 3 to 5 days duration after treatment. 1 patient had nausea and constipation and another had palpitations.

UI	MeSH Term	Description	Entries
D009593	Nitroimidazoles	IMIDAZOLES having a nitro moiety.	Nitroimidazole
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D002986	Clinical Trials as Topic	Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.	Clinical Trial as Topic
D004404	Dysentery, Amebic	DYSENTERY caused by intestinal amebic infection, chiefly with ENTAMOEBA HISTOLYTICA. This condition may be associated with amebic infection of the LIVER and other distant sites.	Amebiasis, Intestinal,Amebic Dysentery,Colitis, Amebic,Entamoebiasis, Intestinal,Intestinal Amebiasis,Amoebiasis, Intestinal,Amoebic Colitis,Amoebic Dysentery,Intestinal Amoebiasis,Intestinal Entamoeba histolytica Infection,Amebiases, Intestinal,Amebic Colitides,Amebic Colitis,Amebic Dysenteries,Amoebiases, Intestinal,Amoebic Colitides,Amoebic Dysenteries,Colitides, Amebic,Colitides, Amoebic,Colitis, Amoebic,Dysenteries, Amebic,Dysenteries, Amoebic,Dysentery, Amoebic,Entamoebiases, Intestinal,Intestinal Amebiases,Intestinal Amoebiases,Intestinal Entamoebiases,Intestinal Entamoebiasis
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D014011	Tinidazole	A nitroimidazole alkylating agent that is used as an antitrichomonal agent against TRICHOMONAS VAGINALIS; ENTAMOEBA HISTOLYTICA; and GIARDIA LAMBLIA infections. It also acts as an antibacterial agent for the treatment of BACTERIAL VAGINOSIS and anaerobic bacterial infections.	Bioshik,CP-12,574,CP-12574,Fasigin,Fasigyn,Fasigyne,Fasygin,Simplotan,Tricolam,CP 12,574,CP 12574,CP12,574,CP12574