BIOMAT Database Logo BIOMAT Database Logo

Nickel oxide nanoparticles induce apoptosis and ferroptosis in airway epithelial cells via ATF3. 2022

Fengfan Liu, and Xiang Cheng, and Shuang Wu, and Bei Hu, and Chen Yang, and Shufen Deng, and Qiwen Shi
Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, Zhejiang, China.

Exposure to nickel oxide nanoparticles (NiONPs), which have been widely produced and applied in industry, leads to adverse pulmonary and systemic effects. The aim of this study is to investigate the involvement of apoptosis and ferroptosis in NiONPs-induced acute lung injury (ALI). Intratracheal instillation of NiONPs into mice elevated the levels of pro-inflammatory cytokines, neutrophils, and proteins in the bronchoalveolar lavage fluid, and triggered apoptosis and ferroptosis in the lung tissues. Consistently, NiONPs-induced apoptosis and ferroptosis were observed in in vitro experiments using human lung epithelial cells. Activating transcription factor 3 (ATF3), a stress-inducible transcription factor, was upregulated by NiONPs exposure in both murine lung tissues and human lung epithelial cells. Moreover, human lung epithelial cells with ATF3 deficiency exhibited a lower level of apoptosis and ferroptosis when exposed to NiONPs. Collectively, our findings demonstrated that ATF3 was responsive to NiONPs exposure, and promoted NiONPs-induced apoptosis and ferroptosis in lung epithelial cells, indicating that ATF3 is a potential biomarker and therapeutic target for NiONPs-associated ALI.

UI MeSH Term Description Entries
D009532 Nickel A trace element with the atomic symbol Ni, atomic number 28, and atomic weight 58.69. It is a cofactor of the enzyme UREASE.
D004847 Epithelial Cells Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells. Adenomatous Epithelial Cells,Columnar Glandular Epithelial Cells,Cuboidal Glandular Epithelial Cells,Glandular Epithelial Cells,Squamous Cells,Squamous Epithelial Cells,Transitional Epithelial Cells,Adenomatous Epithelial Cell,Cell, Adenomatous Epithelial,Cell, Epithelial,Cell, Glandular Epithelial,Cell, Squamous,Cell, Squamous Epithelial,Cell, Transitional Epithelial,Cells, Adenomatous Epithelial,Cells, Epithelial,Cells, Glandular Epithelial,Cells, Squamous,Cells, Squamous Epithelial,Cells, Transitional Epithelial,Epithelial Cell,Epithelial Cell, Adenomatous,Epithelial Cell, Glandular,Epithelial Cell, Squamous,Epithelial Cell, Transitional,Epithelial Cells, Adenomatous,Epithelial Cells, Glandular,Epithelial Cells, Squamous,Epithelial Cells, Transitional,Glandular Epithelial Cell,Squamous Cell,Squamous Epithelial Cell,Transitional Epithelial Cell
D000079403 Ferroptosis A form of REGULATED CELL DEATH initiated by oxidative perturbations of the intracellular microenvironment that is under constitutive control by glutathione peroxidase 4 and can be inhibited by iron chelators and lipophilic antioxidants. Oxytosis
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D017209 Apoptosis A regulated cell death mechanism characterized by distinctive morphologic changes in the nucleus and cytoplasm, including the endonucleolytic cleavage of genomic DNA, at regularly spaced, internucleosomal sites, i.e., DNA FRAGMENTATION. It is genetically programmed and serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. Apoptosis, Extrinsic Pathway,Apoptosis, Intrinsic Pathway,Caspase-Dependent Apoptosis,Classic Apoptosis,Classical Apoptosis,Programmed Cell Death,Programmed Cell Death, Type I,Apoptoses, Extrinsic Pathway,Apoptoses, Intrinsic Pathway,Apoptosis, Caspase-Dependent,Apoptosis, Classic,Apoptosis, Classical,Caspase Dependent Apoptosis,Cell Death, Programmed,Classic Apoptoses,Extrinsic Pathway Apoptoses,Extrinsic Pathway Apoptosis,Intrinsic Pathway Apoptoses,Intrinsic Pathway Apoptosis
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D051700 Activating Transcription Factor 3 An activating transcription factor that plays a key role in cellular responses to GENOTOXIC STRESS and OXIDATIVE STRESS. ATF3 Transcription Factor,Activating Transcription Factor-3,Transcription Factor, ATF3
D053758 Nanoparticles Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging. Nanocrystalline Materials,Nanocrystals,Material, Nanocrystalline,Materials, Nanocrystalline,Nanocrystal,Nanocrystalline Material,Nanoparticle

Related Publications

Fengfan Liu, and Xiang Cheng, and Shuang Wu, and Bei Hu, and Chen Yang, and Shufen Deng, and Qiwen Shi
Nickel nanoparticles induce autophagy and apoptosis via HIF-1α/mTOR signaling in human bronchial epithelial cells.
July 2023, Environmental pollution (Barking, Essex : 1987),
Fengfan Liu, and Xiang Cheng, and Shuang Wu, and Bei Hu, and Chen Yang, and Shufen Deng, and Qiwen Shi
Nickel oxide nanoparticles induce inflammation and genotoxic effect in lung epithelial cells.
April 2014, Toxicology letters,
Fengfan Liu, and Xiang Cheng, and Shuang Wu, and Bei Hu, and Chen Yang, and Shufen Deng, and Qiwen Shi
Copper oxide nanoparticles induce oxidative stress and cytotoxicity in airway epithelial cells.
October 2009, Toxicology in vitro : an international journal published in association with BIBRA,
Fengfan Liu, and Xiang Cheng, and Shuang Wu, and Bei Hu, and Chen Yang, and Shufen Deng, and Qiwen Shi
Copper oxide nanoparticles induce collagen deposition via TGF-β1/Smad3 signaling in human airway epithelial cells.
April 2018, Nanotoxicology,
Fengfan Liu, and Xiang Cheng, and Shuang Wu, and Bei Hu, and Chen Yang, and Shufen Deng, and Qiwen Shi
Nickel oxide nanoparticles induce hepatocyte apoptosis via activating endoplasmic reticulum stress pathways in rats.
December 2017, Environmental toxicology,
Fengfan Liu, and Xiang Cheng, and Shuang Wu, and Bei Hu, and Chen Yang, and Shufen Deng, and Qiwen Shi
Nickel nanoparticles induce epithelial-mesenchymal transition in human bronchial epithelial cells via the HIF-1α/HDAC3 pathway.
January 2022, Nanotoxicology,
Fengfan Liu, and Xiang Cheng, and Shuang Wu, and Bei Hu, and Chen Yang, and Shufen Deng, and Qiwen Shi
Nickel mobilizes intracellular zinc to induce metallothionein in human airway epithelial cells.
July 2009, American journal of respiratory cell and molecular biology,
Fengfan Liu, and Xiang Cheng, and Shuang Wu, and Bei Hu, and Chen Yang, and Shufen Deng, and Qiwen Shi
Nickel nanoparticles induce hepatotoxicity via oxidative and nitrative stress-mediated apoptosis and inflammation.
October 2021, Toxicology and industrial health,
Fengfan Liu, and Xiang Cheng, and Shuang Wu, and Bei Hu, and Chen Yang, and Shufen Deng, and Qiwen Shi
Nickel oxide nanoparticles exert cytotoxicity via oxidative stress and induce apoptotic response in human liver cells (HepG2).
November 2013, Chemosphere,
Fengfan Liu, and Xiang Cheng, and Shuang Wu, and Bei Hu, and Chen Yang, and Shufen Deng, and Qiwen Shi
Cuprous oxide nanoparticles selectively induce apoptosis of tumor cells.
January 2012, International journal of nanomedicine,
Copied contents to your clipboard!