BIOMAT Database Logo BIOMAT Database Logo

The unfolded protein response and the biology of uveal melanoma. 2022

Stanley Zhang, and Ke Wang, and Xue Zhu, and Svetlana Cherepanoff, and R Max Conway, and Michele C Madigan, and Ling Zhu, and Michael Murray, and Fanfan Zhou
Sydney Pharmacy School, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, 2006, Australia; Discipline of Pharmacology, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, 2006, Australia.

Uveal melanoma (UM) is a highly metastatic ocular cancer that arises from the melanocytes of the uveal tract (the choroid, ciliary body and iris). Despite a growing understanding of UM biology, effective systemic treatments are currently lacking and the cancer has an extremely poor prognosis. Therefore, identifying novel agents that act by new tumorigenic mechanisms in UM is essential to address this unmet clinical need. Endoplasmic reticulum (ER) stress occurs when misfolded proteins accumulate in the organelle, and the unfolded protein response (UPR) is the cellular mechanism that is activated so that cells may adapt to the situation. Dysregulated UPR signalling has been detected in UM tumors and has been associated with an increase in immune evasion and metastatic activity. A number of established and novel oncology drugs act in part by modulating ER stress and the UPR. The induction of protein-folding stress and the UPR could be a novel approach for the development of new therapeutics in UM. Further studies are now warranted to understand the mechanisms and consequences of UPR signalling in UM.

UI MeSH Term Description Entries
D008545 Melanoma A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445) Malignant Melanoma,Malignant Melanomas,Melanoma, Malignant,Melanomas,Melanomas, Malignant
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001695 Biology One of the BIOLOGICAL SCIENCE DISCIPLINES concerned with the origin, structure, development, growth, function, genetics, and reproduction of animals, plants, and microorganisms.
D014604 Uveal Neoplasms Tumors or cancer of the UVEA. Neoplasm, Uveal,Neoplasms, Uveal,Uveal Neoplasm
D056811 Unfolded Protein Response A cellular response to environmental insults that cause disruptions in PROTEIN FOLDING and/or accumulation of defectively folded protein in the ENDOPLASMIC RETICULUM. It consists of a group of regulatory cascades that are triggered as a response to altered levels of calcium and/or the redox state of the endoplasmic reticulum. Persistent activation of the unfolded protein response leads to the induction of APOPTOSIS. Protein Response, Unfolded,Protein Responses, Unfolded,Response, Unfolded Protein,Responses, Unfolded Protein,Unfolded Protein Responses
D059865 Endoplasmic Reticulum Stress Various physiological or molecular disturbances that impair ENDOPLASMIC RETICULUM function. It triggers many responses, including UNFOLDED PROTEIN RESPONSE, which may lead to APOPTOSIS; and AUTOPHAGY. Stress, Endoplasmic Reticulum,Endoplasmic Reticulum Stresses,Reticulum Stress, Endoplasmic,Reticulum Stresses, Endoplasmic,Stresses, Endoplasmic Reticulum

Related Publications

Stanley Zhang, and Ke Wang, and Xue Zhu, and Svetlana Cherepanoff, and R Max Conway, and Michele C Madigan, and Ling Zhu, and Michael Murray, and Fanfan Zhou
Melanoma and the Unfolded Protein Response.
February 2016, Cancers,
Stanley Zhang, and Ke Wang, and Xue Zhu, and Svetlana Cherepanoff, and R Max Conway, and Michele C Madigan, and Ling Zhu, and Michael Murray, and Fanfan Zhou
The biology of uveal melanoma.
March 2017, Cancer metastasis reviews,
Stanley Zhang, and Ke Wang, and Xue Zhu, and Svetlana Cherepanoff, and R Max Conway, and Michele C Madigan, and Ling Zhu, and Michael Murray, and Fanfan Zhou
The cell biology of the unfolded protein response.
July 2011, Gastroenterology,
Stanley Zhang, and Ke Wang, and Xue Zhu, and Svetlana Cherepanoff, and R Max Conway, and Michele C Madigan, and Ling Zhu, and Michael Murray, and Fanfan Zhou
The biology and management of uveal melanoma.
September 2008, Current oncology reports,
Stanley Zhang, and Ke Wang, and Xue Zhu, and Svetlana Cherepanoff, and R Max Conway, and Michele C Madigan, and Ling Zhu, and Michael Murray, and Fanfan Zhou
The biology of micrometastases from uveal melanoma.
August 2011, Journal of clinical pathology,
Stanley Zhang, and Ke Wang, and Xue Zhu, and Svetlana Cherepanoff, and R Max Conway, and Michele C Madigan, and Ling Zhu, and Michael Murray, and Fanfan Zhou
Metastatic uveal melanoma: biology and emerging treatments.
January 2012, Cancer journal (Sudbury, Mass.),
Stanley Zhang, and Ke Wang, and Xue Zhu, and Svetlana Cherepanoff, and R Max Conway, and Michele C Madigan, and Ling Zhu, and Michael Murray, and Fanfan Zhou
The unfolded protein and integrated stress response in melanoma and vitiligo.
March 2021, Pigment cell & melanoma research,
Stanley Zhang, and Ke Wang, and Xue Zhu, and Svetlana Cherepanoff, and R Max Conway, and Michele C Madigan, and Ling Zhu, and Michael Murray, and Fanfan Zhou
When is the unfolded protein response not the unfolded protein response?
July 2017, Plant science : an international journal of experimental plant biology,
Stanley Zhang, and Ke Wang, and Xue Zhu, and Svetlana Cherepanoff, and R Max Conway, and Michele C Madigan, and Ling Zhu, and Michael Murray, and Fanfan Zhou
Uveal melanoma: progress in molecular biology and therapeutics.
January 2020, Therapeutic advances in medical oncology,
Stanley Zhang, and Ke Wang, and Xue Zhu, and Svetlana Cherepanoff, and R Max Conway, and Michele C Madigan, and Ling Zhu, and Michael Murray, and Fanfan Zhou
Latest developments in the biology and management of uveal melanoma.
December 2013, Current oncology reports,
Copied contents to your clipboard!