-transparent.png){kind=logo}
Calcitonin is known to inhibit secretion of gastrin and insulin in vivo. The objective of this study was to determine whether calcitonin can act directly on pancreatic islets in vitro to inhibit insulin release. Isolated islets were obtained from collagenase-treated rat pancreas, and three peptides (gastrin-releasing peptide, cholecystokinin-8, bombesin) and glucose were used to stimulate insulin release. All agents caused a significant increase in insulin secretion and calcitonin inhibited these responses, but had no consistent effect on basal release. This study provides evidence that calcitonin is an effective inhibitor of insulin secretion and acts directly on islet tissue.
A Alwmark, and
M W Stavinoha, and
C W Cooper, and
G H Greeley, and
J C Thompson
January 1994,
Fundamental & clinical pharmacology,
A Alwmark, and
M W Stavinoha, and
C W Cooper, and
G H Greeley, and
J C Thompson
February 1974,
Diabetologia,
A Alwmark, and
M W Stavinoha, and
C W Cooper, and
G H Greeley, and
J C Thompson
June 1975,
FEBS letters,
A Alwmark, and
M W Stavinoha, and
C W Cooper, and
G H Greeley, and
J C Thompson
June 1993,
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae,
A Alwmark, and
M W Stavinoha, and
C W Cooper, and
G H Greeley, and
J C Thompson
November 2008,
Journal of ethnopharmacology,
A Alwmark, and
M W Stavinoha, and
C W Cooper, and
G H Greeley, and
J C Thompson
August 1980,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
A Alwmark, and
M W Stavinoha, and
C W Cooper, and
G H Greeley, and
J C Thompson
May 1970,
Science (New York, N.Y.),
A Alwmark, and
M W Stavinoha, and
C W Cooper, and
G H Greeley, and
J C Thompson
October 1976,
FEBS letters,
A Alwmark, and
M W Stavinoha, and
C W Cooper, and
G H Greeley, and
J C Thompson
July 1983,
Biochemical and biophysical research communications,
A Alwmark, and
M W Stavinoha, and
C W Cooper, and
G H Greeley, and
J C Thompson
May 2006,
Life sciences,
