Biomaterial Database

Asystole-induced Bradycardia by Dexmedetomidine during Endoscopic Submucosal Dissection. 2022

Tomoaki Yamasaki, and Yuhei Sakata, and Takehisa Suekane, and Hiroko Nebiki

Department of Gastroenterology, Osaka City General Hospital, Japan.

Although dexmedetomidine (DEX) is a widely used analgesic and sedative agent for endoscopic procedures, cardiovascular complications, such as bradycardia and hypotension, are frequently experienced. We herein report the first case of asystole-induced bradycardia due to DEX during endoscopic submucosal dissection (ESD). An 81-year-old man without cardiovascular diseases was referred for gastric carcinoma. ESD was started after administering a loading dose of DEX followed by a continuous maintenance infusion of DEX. The patient's heart rate gradually decreased, and then cardiac arrest occurred. DEX has a risk of cardiac arrest, so bradycardia should not be underestimated during sedation with DEX.

UI	MeSH Term	Description	Entries
D006993	Hypnotics and Sedatives	Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.	Hypnotic,Sedative,Sedative and Hypnotic,Sedatives,Hypnotic Effect,Hypnotic Effects,Hypnotics,Sedative Effect,Sedative Effects,Sedatives and Hypnotics,Effect, Hypnotic,Effect, Sedative,Effects, Hypnotic,Effects, Sedative,Hypnotic and Sedative
D008297	Male		Males
D001919	Bradycardia	Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. They can be classified broadly into SINOATRIAL NODE dysfunction and ATRIOVENTRICULAR BLOCK.	Bradyarrhythmia,Bradyarrhythmias,Bradycardias
D006323	Heart Arrest	Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most cases to normal cardiac rhythm and effective circulation.	Asystole,Cardiac Arrest,Cardiopulmonary Arrest,Arrest, Cardiac,Arrest, Cardiopulmonary,Arrest, Heart,Asystoles
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000069916	Endoscopic Mucosal Resection	A method for removing lesions from gastrointestinal MUCOUS MEMBRANES. The mucosal tissue with the lesion is elevated by injecting a solution into the submucosal layer underneath it. The elevated tissue with the lesion is then cut out.	Endoscopic Full Thickness Resection,Submucosal Tunneling Endoscopic Resection,Endoscopic Mucous Membrane Resection,Endoscopic Submucosal Dissection,Strip Biopsy,Biopsy, Strip,Dissection, Endoscopic Submucosal,Endoscopic Mucosal Resections,Endoscopic Submucosal Dissections,Mucosal Resection, Endoscopic,Resection, Endoscopic Mucosal,Strip Biopsies,Submucosal Dissection, Endoscopic
D000369	Aged, 80 and over	Persons 80 years of age and older.	Oldest Old
D020927	Dexmedetomidine	An imidazole derivative that is an agonist of ADRENERGIC ALPHA-2 RECEPTORS. It is closely related to MEDETOMIDINE, which is the racemic form of this compound.	Cepedex,Dexdomitor,Dexdor,Igalmi,Sedadex,Sileo,Dexmedetomidine Hydrochloride,MPV-1440,Precedex,Hydrochloride, Dexmedetomidine,MPV 1440,MPV1440