-transparent.png){kind=logo}
Klebsiella vaccines were isolated by mild diafiltration techniques from culture filtrates of nine capsular types of K. aerogenes (K1, K2, K3, K15, K20, K35, K36, K44 & K63). The bacteria were grown in a chemically defined medium in standardized conditions in a fermenter. The vaccines had a molecular weight of more than 20 000, a carbohydrate content of 40-89%, a protein content of between less than 1 and 16% and small amounts (0.6-1.2%) of lipopolysaccharide. Antisera raised in rabbits to the nine klebsiella vaccines were standardized by passive haemagglutination, immunoglobulin G enzyme-linked immunosorbent assay and by autologous passive protection tests. Each rabbit antiserum when passively transferred to mice showed a variable capacity to passively protect mice against lethal infections by a panel of ten capsular types of K. aerogenes (K1-K10). Seven of the rabbit antisera protected mice against more than half of the challenge strains. A pool of six rabbit antisera (anti-K1, K2, K3, K20, K35 & K44) passively protected mice against lethal infections from strains of bacteria representing each of 77 capsular types of K. aerogenes.
E A Roe, and
R J Jones, and
R E Dyster
February 1968,
Sabouraudia,
E A Roe, and
R J Jones, and
R E Dyster
October 1953,
Cancer research,
E A Roe, and
R J Jones, and
R E Dyster
April 1988,
The Journal of parasitology,
E A Roe, and
R J Jones, and
R E Dyster
June 1947,
British medical journal,
E A Roe, and
R J Jones, and
R E Dyster
January 1965,
Archiv fur die gesamte Virusforschung,
E A Roe, and
R J Jones, and
R E Dyster
January 1955,
Monograph series. World Health Organization,
E A Roe, and
R J Jones, and
R E Dyster
January 1970,
Molecular & general genetics : MGG,
E A Roe, and
R J Jones, and
R E Dyster
November 1969,
Acta virologica,
E A Roe, and
R J Jones, and
R E Dyster
June 1977,
Tropenmedizin und Parasitologie,
E A Roe, and
R J Jones, and
R E Dyster
May 1969,
The New England journal of medicine,
