A tiered approach to investigate the inhalation toxicity of cobalt substances. Tier 4: Effects from a 28-day inhalation toxicity study with tricobalt tetraoxide in rats. 2022

Arne Burzlaff, and Otto Creutzenberg, and Dirk Schaudien, and Vanessa Viegas, and Ruth Danzeisen, and David Warheit
EBRC Consulting GmbH, Raffaelstr. 4, 30177, Hannover, Germany. Electronic address: a.burzlaff@ebrc.de.

Lung cancer following inhalation in rodents is a major concern regarding exposure to cobalt substances. However, little information is available on adverse effects and toxicity following long-term inhalation exposure to poorly soluble cobalt substances with low bioavailability. Thus, the present study focused on pulmonary effects of the poorly soluble tricobalt tetraoxide (5, 20, 80 mg/m³) in a 28-day inhalation exposure study. Lung weights increased with increasing exposures. Bronchoalveolar lavage fluid analysis and histopathology revealed lung tissue inflammation at the mid-dose with increasing severity in the high-dose group and post-exposure persistency. Markers for cellular damage and cell proliferation were statistically significantly increased. No increase in 8-OH-dG lesions was observed, indicating an absence of oxidative DNA lesions. The primary effect of inhaled Co3O4 particles is inflammation of the respiratory tract strongly resembling responses of inhaled "inert dust" substances, with a NOAEC of 5 mg/m³ under the conditions of this test.

UI MeSH Term Description Entries
D008168 Lung Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood. Lungs
D008297 Male Males
D010087 Oxides Binary compounds of oxygen containing the anion O(2-). The anion combines with metals to form alkaline oxides and non-metals to form acidic oxides. Oxide
D010316 Particle Size Relating to the size of solids. Particle Sizes,Size, Particle,Sizes, Particle
D011014 Pneumonia Infection of the lung often accompanied by inflammation. Experimental Lung Inflammation,Lobar Pneumonia,Lung Inflammation,Pneumonia, Lobar,Pneumonitis,Pulmonary Inflammation,Experimental Lung Inflammations,Inflammation, Experimental Lung,Inflammation, Lung,Inflammation, Pulmonary,Inflammations, Lung,Inflammations, Pulmonary,Lobar Pneumonias,Lung Inflammation, Experimental,Lung Inflammations,Lung Inflammations, Experimental,Pneumonias,Pneumonias, Lobar,Pneumonitides,Pulmonary Inflammations
D011897 Random Allocation A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects. Randomization,Allocation, Random
D001992 Bronchoalveolar Lavage Fluid Washing liquid obtained from irrigation of the lung, including the BRONCHI and the PULMONARY ALVEOLI. It is generally used to assess biochemical, inflammatory, or infection status of the lung. Alveolar Lavage Fluid,Bronchial Lavage Fluid,Lung Lavage Fluid,Bronchial Alveolar Lavage Fluid,Lavage Fluid, Bronchial,Lavage Fluid, Lung,Pulmonary Lavage Fluid,Alveolar Lavage Fluids,Bronchial Lavage Fluids,Bronchoalveolar Lavage Fluids,Lavage Fluid, Alveolar,Lavage Fluid, Bronchoalveolar,Lavage Fluid, Pulmonary,Lavage Fluids, Alveolar,Lavage Fluids, Bronchial,Lavage Fluids, Bronchoalveolar,Lavage Fluids, Lung,Lavage Fluids, Pulmonary,Lung Lavage Fluids,Pulmonary Lavage Fluids
D003035 Cobalt A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis. Cobalt-59,Cobalt 59
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D005260 Female Females

Related Publications

Arne Burzlaff, and Otto Creutzenberg, and Dirk Schaudien, and Vanessa Viegas, and Ruth Danzeisen, and David Warheit
March 2022, Regulatory toxicology and pharmacology : RTP,
Arne Burzlaff, and Otto Creutzenberg, and Dirk Schaudien, and Vanessa Viegas, and Ruth Danzeisen, and David Warheit
April 2022, Regulatory toxicology and pharmacology : RTP,
Arne Burzlaff, and Otto Creutzenberg, and Dirk Schaudien, and Vanessa Viegas, and Ruth Danzeisen, and David Warheit
March 2022, Regulatory toxicology and pharmacology : RTP,
Arne Burzlaff, and Otto Creutzenberg, and Dirk Schaudien, and Vanessa Viegas, and Ruth Danzeisen, and David Warheit
April 2022, Regulatory toxicology and pharmacology : RTP,
Arne Burzlaff, and Otto Creutzenberg, and Dirk Schaudien, and Vanessa Viegas, and Ruth Danzeisen, and David Warheit
April 2022, Regulatory toxicology and pharmacology : RTP,
Arne Burzlaff, and Otto Creutzenberg, and Dirk Schaudien, and Vanessa Viegas, and Ruth Danzeisen, and David Warheit
January 2018, Toxicology reports,
Arne Burzlaff, and Otto Creutzenberg, and Dirk Schaudien, and Vanessa Viegas, and Ruth Danzeisen, and David Warheit
September 2016, Nanotoxicology,
Arne Burzlaff, and Otto Creutzenberg, and Dirk Schaudien, and Vanessa Viegas, and Ruth Danzeisen, and David Warheit
January 1994, Toxicology and industrial health,
Arne Burzlaff, and Otto Creutzenberg, and Dirk Schaudien, and Vanessa Viegas, and Ruth Danzeisen, and David Warheit
February 1989, Fundamental and applied toxicology : official journal of the Society of Toxicology,
Arne Burzlaff, and Otto Creutzenberg, and Dirk Schaudien, and Vanessa Viegas, and Ruth Danzeisen, and David Warheit
July 2017, Particle and fibre toxicology,
Copied contents to your clipboard!