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Forty patients presenting with first episode genital herpes were randomly allocated to seven day treatment with oral acyclovir alone, placebo alone, oral acyclovir plus co-trimoxazole, or placebo plus co-trimoxazole. Patients receiving acyclovir had significantly shorter periods of viral shedding (p less than 0.001), pain (p = 0.03), and times to lesion healing (p less than 0.05). Averaged over all patients there was no evidence that co-trimoxazole affected any of the variables, though in women cotrimoxazole was associated with a shorter time to lesion healing (p less than 0.01). Furthermore, the combination treatment gave significantly shorter times to lesion healing than acyclovir alone, placebo alone, or placebo and co-trimoxazole (p = 0.01) and good trends elsewhere (external lesions and duration of pain). Neither drug was associated with any adverse events or toxicity or influenced the subsequent recurrence rate.
G R Kinghorn, and
I Abeywickreme, and
M Jeavons, and
M Rowland, and
I Barton, and
G Al-Hasani, and
C W Potter, and
E Hickmott
April 1988,
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases,
G R Kinghorn, and
I Abeywickreme, and
M Jeavons, and
M Rowland, and
I Barton, and
G Al-Hasani, and
C W Potter, and
E Hickmott
January 1985,
Scandinavian journal of infectious diseases. Supplementum,
G R Kinghorn, and
I Abeywickreme, and
M Jeavons, and
M Rowland, and
I Barton, and
G Al-Hasani, and
C W Potter, and
E Hickmott
January 1985,
Sexually transmitted diseases,
G R Kinghorn, and
I Abeywickreme, and
M Jeavons, and
M Rowland, and
I Barton, and
G Al-Hasani, and
C W Potter, and
E Hickmott
September 1983,
The Journal of antimicrobial chemotherapy,
G R Kinghorn, and
I Abeywickreme, and
M Jeavons, and
M Rowland, and
I Barton, and
G Al-Hasani, and
C W Potter, and
E Hickmott
September 1983,
The Journal of antimicrobial chemotherapy,
G R Kinghorn, and
I Abeywickreme, and
M Jeavons, and
M Rowland, and
I Barton, and
G Al-Hasani, and
C W Potter, and
E Hickmott
May 1988,
JAMA,
G R Kinghorn, and
I Abeywickreme, and
M Jeavons, and
M Rowland, and
I Barton, and
G Al-Hasani, and
C W Potter, and
E Hickmott
February 1975,
The British journal of clinical practice,
G R Kinghorn, and
I Abeywickreme, and
M Jeavons, and
M Rowland, and
I Barton, and
G Al-Hasani, and
C W Potter, and
E Hickmott
August 1986,
Journal of the American Academy of Dermatology,
G R Kinghorn, and
I Abeywickreme, and
M Jeavons, and
M Rowland, and
I Barton, and
G Al-Hasani, and
C W Potter, and
E Hickmott
September 1982,
Lancet (London, England),
G R Kinghorn, and
I Abeywickreme, and
M Jeavons, and
M Rowland, and
I Barton, and
G Al-Hasani, and
C W Potter, and
E Hickmott
September 1984,
JAMA,
