-transparent.png){kind=logo}
Plant components with bio-antimutagenic activity were screened on UVC (254 nm)-induced mutagenesis using E. coli B/r WP2. The components with a pyrogallol moiety including gallic acid, (-)-epicatechin gallate (ECG), (-)-epigallocatechin (EGC) and (-)-epigallocatechin gallate (EGCG) reduced the mutation induction, but other components such as caffeic acid, chlorogenic acid and quercetin did not. The above compounds with a pyrogallol moiety were also effective on UVAB (295-400 nm)-induced mutagenesis, while they showed little effect on N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced mutagenesis. As this bio-antimutagenic effect was not seen in the DNA excision-repair-deficient strains WP2s and ZA159, the activity by the above plant components might be based on the promotion of the excision-repair system in E. coli B/r WP2.
K Shimoi, and
Y Nakamura, and
I Tomita, and
Y Hara, and
T Kada
December 1982,
International journal of radiation biology and related studies in physics, chemistry, and medicine,
K Shimoi, and
Y Nakamura, and
I Tomita, and
Y Hara, and
T Kada
January 1992,
Bioscience, biotechnology, and biochemistry,
K Shimoi, and
Y Nakamura, and
I Tomita, and
Y Hara, and
T Kada
October 1977,
Mutation research,
K Shimoi, and
Y Nakamura, and
I Tomita, and
Y Hara, and
T Kada
October 1984,
Journal of bacteriology,
K Shimoi, and
Y Nakamura, and
I Tomita, and
Y Hara, and
T Kada
February 1998,
Mutation research,
K Shimoi, and
Y Nakamura, and
I Tomita, and
Y Hara, and
T Kada
January 1982,
Folia microbiologica,
K Shimoi, and
Y Nakamura, and
I Tomita, and
Y Hara, and
T Kada
January 1982,
Folia microbiologica,
K Shimoi, and
Y Nakamura, and
I Tomita, and
Y Hara, and
T Kada
June 1974,
Mutation research,
K Shimoi, and
Y Nakamura, and
I Tomita, and
Y Hara, and
T Kada
January 1967,
Mutation research,
K Shimoi, and
Y Nakamura, and
I Tomita, and
Y Hara, and
T Kada
December 1976,
Biochimica et biophysica acta,
