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A multi-center study was carried out to compare the healing rates of ranitidine 300 mg nocte and 150 mg b.i.d. in the short-term treatment of gastric ulcers and to assess the side-effect liability of ranitidine 300 mg given in a single daily dose. Forty-five outpatients suffering from endoscopically and bioptically proven uncomplicated benign gastric ulcer were selected for the study. The patients were treated, for 4 weeks, on the basis of a double-blind randomized design. An endoscopic examination was repeated within 4 days after the end of the treatments. The patients who did not demonstrate complete healing were treated for an additional 4-week period. Clinical controls were performed to evaluate symptoms, antacid consumption, compliance with trial tablet consumption; hematological and biochemical tests were also carried out at the end of the 4 and 8-week periods. No differences were observed between the healing rate induced by 300 mg nocte and 150 mg b.i.d., after 4 weeks of treatment (76% and 79% respectively) and after 8 weeks (100% in both groups). Similar results were obtained as far as symptoms, antacid consumption and compliance are concerned. Neither treatment regimen induced appreciable side-effects.
L Barbara, and
R Corinaldesi, and
S Adamo, and
V Comin, and
G Dobrilla, and
A Giacosa, and
O Ghidini, and
C Huscher, and
E Panza
July 1986,
International journal of clinical pharmacology, therapy, and toxicology,
L Barbara, and
R Corinaldesi, and
S Adamo, and
V Comin, and
G Dobrilla, and
A Giacosa, and
O Ghidini, and
C Huscher, and
E Panza
February 1990,
Zeitschrift fur Gastroenterologie,
L Barbara, and
R Corinaldesi, and
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A Giacosa, and
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C Huscher, and
E Panza
April 1988,
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L Barbara, and
R Corinaldesi, and
S Adamo, and
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A Giacosa, and
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C Huscher, and
E Panza
January 1992,
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L Barbara, and
R Corinaldesi, and
S Adamo, and
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A Giacosa, and
O Ghidini, and
C Huscher, and
E Panza
August 1987,
Hepato-gastroenterology,
L Barbara, and
R Corinaldesi, and
S Adamo, and
V Comin, and
G Dobrilla, and
A Giacosa, and
O Ghidini, and
C Huscher, and
E Panza
September 1985,
The American journal of gastroenterology,
L Barbara, and
R Corinaldesi, and
S Adamo, and
V Comin, and
G Dobrilla, and
A Giacosa, and
O Ghidini, and
C Huscher, and
E Panza
January 1985,
European journal of clinical pharmacology,
L Barbara, and
R Corinaldesi, and
S Adamo, and
V Comin, and
G Dobrilla, and
A Giacosa, and
O Ghidini, and
C Huscher, and
E Panza
December 1993,
Alimentary pharmacology & therapeutics,
L Barbara, and
R Corinaldesi, and
S Adamo, and
V Comin, and
G Dobrilla, and
A Giacosa, and
O Ghidini, and
C Huscher, and
E Panza
December 1990,
Hepato-gastroenterology,
L Barbara, and
R Corinaldesi, and
S Adamo, and
V Comin, and
G Dobrilla, and
A Giacosa, and
O Ghidini, and
C Huscher, and
E Panza
October 1987,
Hepato-gastroenterology,
