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We studied the efficacy of (1) preventing the development of serous otitis media (SOM) by using an oral decongestant in children with acute otitis media and (2) treating SOM with an oral decongestant. In a randomized double-blind study, 190 children were treated for acute otitis media with antibiotics and either pseudoephedrine hydrochloride (Sudafed) or placebo. They were evaluated two weeks later by tympanometry and (independently) by clinical evaluation and pneumotoscopy. There were no significant differences between the two groups, except that males developed SOM significantly more often than did females. Use of decongestant and placebo was continued in 78 patients with SOM for up to four more weeks. Again, there were no siginificant differences between the treatment groups except that patients with an allergic history did significantly worse using a decongestant. Overall there was no benefit from pseudoephedrine in either the prevention or treatment of SOM.
A L Olson, and
S W Klein, and
E Charney, and
J B MacWhinney, and
T K McInerny, and
R L Miller, and
L F Nazarian, and
D Cunningham
September 1979,
International journal of pediatric otorhinolaryngology,
A L Olson, and
S W Klein, and
E Charney, and
J B MacWhinney, and
T K McInerny, and
R L Miller, and
L F Nazarian, and
D Cunningham
September 1982,
Missouri medicine,
A L Olson, and
S W Klein, and
E Charney, and
J B MacWhinney, and
T K McInerny, and
R L Miller, and
L F Nazarian, and
D Cunningham
October 1981,
The Journal of otolaryngology,
A L Olson, and
S W Klein, and
E Charney, and
J B MacWhinney, and
T K McInerny, and
R L Miller, and
L F Nazarian, and
D Cunningham
September 1974,
The New England journal of medicine,
A L Olson, and
S W Klein, and
E Charney, and
J B MacWhinney, and
T K McInerny, and
R L Miller, and
L F Nazarian, and
D Cunningham
January 1972,
Current therapeutic research, clinical and experimental,
A L Olson, and
S W Klein, and
E Charney, and
J B MacWhinney, and
T K McInerny, and
R L Miller, and
L F Nazarian, and
D Cunningham
October 1980,
Ugeskrift for laeger,
A L Olson, and
S W Klein, and
E Charney, and
J B MacWhinney, and
T K McInerny, and
R L Miller, and
L F Nazarian, and
D Cunningham
February 1983,
The New England journal of medicine,
A L Olson, and
S W Klein, and
E Charney, and
J B MacWhinney, and
T K McInerny, and
R L Miller, and
L F Nazarian, and
D Cunningham
June 1961,
The Ohio State medical journal,
A L Olson, and
S W Klein, and
E Charney, and
J B MacWhinney, and
T K McInerny, and
R L Miller, and
L F Nazarian, and
D Cunningham
October 1980,
Ugeskrift for laeger,
A L Olson, and
S W Klein, and
E Charney, and
J B MacWhinney, and
T K McInerny, and
R L Miller, and
L F Nazarian, and
D Cunningham
October 1980,
Bulletin of the New York Academy of Medicine,
