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The present study examined the effects of physostigmine, a cholinesterase inhibitor, on activity in young rats whose mothers consumed isocaloric liquid diets containing 35% or 0% ethanol-derived calories on days 6-20 of pregnancy. A pair-feeding procedure was utilized and an ad libitum lab chow group was included. Physostigmine was administered to 18-day-old offspring on 3 consecutive days with activity measures recorded for 30 min each day. Injections of physostigmine produced significant reductions in activity in alcohol-exposed offspring relative to control groups. These results provide support for a functional cholinergic deficit in offspring exposed to alcohol in utero and may have relevant clinical implications in the treatment of attentional deficit disorder which can occur following prenatal alcohol exposure.
E P Riley, and
S Barron, and
C D Driscoll, and
R T Hamlin
January 1988,
Alcohol (Fayetteville, N.Y.),
E P Riley, and
S Barron, and
C D Driscoll, and
R T Hamlin
January 1991,
Acta Universitatis Palackianae Olomucensis Facultatis Medicae,
E P Riley, and
S Barron, and
C D Driscoll, and
R T Hamlin
January 1986,
Neurobehavioral toxicology and teratology,
E P Riley, and
S Barron, and
C D Driscoll, and
R T Hamlin
January 1969,
Developmental psychobiology,
E P Riley, and
S Barron, and
C D Driscoll, and
R T Hamlin
October 1982,
Teratology,
E P Riley, and
S Barron, and
C D Driscoll, and
R T Hamlin
January 1990,
Neurotoxicology and teratology,
E P Riley, and
S Barron, and
C D Driscoll, and
R T Hamlin
April 1972,
Psychological reports,
E P Riley, and
S Barron, and
C D Driscoll, and
R T Hamlin
February 1979,
Pharmacology, biochemistry, and behavior,
E P Riley, and
S Barron, and
C D Driscoll, and
R T Hamlin
January 1996,
Life sciences,
E P Riley, and
S Barron, and
C D Driscoll, and
R T Hamlin
January 1983,
Neurobehavioral toxicology and teratology,
