Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals. 1986

K Mortelmans, and S Haworth, and T Lawlor, and W Speck, and B Tainer, and E Zeiger

This publication includes data of Salmonella mutagenicity results on 270 coded chemicals, encompassing 329 tests performed by three laboratories under contract to the National Toxicology Program (NTP). The preincubation modification of the Salmonella/mammalian microsome assay was used to test chemicals in up to five Salmonella strains in the presence and absence of rat and hamster liver S-9. With a few exceptions, inter- and intralaboratory reproducibility was good.

UI MeSH Term Description Entries
D008862 Microsomes, Liver Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough. Liver Microsomes,Liver Microsome,Microsome, Liver
D009152 Mutagenicity Tests Tests of chemical substances and physical agents for mutagenic potential. They include microbial, insect, mammalian cell, and whole animal tests. Genetic Toxicity Tests,Genotoxicity Tests,Mutagen Screening,Tests, Genetic Toxicity,Toxicity Tests, Genetic,Genetic Toxicity Test,Genotoxicity Test,Mutagen Screenings,Mutagenicity Test,Screening, Mutagen,Screenings, Mutagen,Test, Genotoxicity,Tests, Genotoxicity,Toxicity Test, Genetic
D009153 Mutagens Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes. Clastogen,Clastogens,Genotoxin,Genotoxins,Mutagen
D006224 Cricetinae A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS. Cricetus,Hamsters,Hamster
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001711 Biotransformation The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
D012486 Salmonella typhimurium A serotype of Salmonella enterica that is a frequent agent of Salmonella gastroenteritis in humans. It also causes PARATYPHOID FEVER. Salmonella typhimurium LT2
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

K Mortelmans, and S Haworth, and T Lawlor, and W Speck, and B Tainer, and E Zeiger
January 1955, Cancer research,
K Mortelmans, and S Haworth, and T Lawlor, and W Speck, and B Tainer, and E Zeiger
January 1990, Environmental and molecular mutagenesis,
K Mortelmans, and S Haworth, and T Lawlor, and W Speck, and B Tainer, and E Zeiger
October 1982, Mutation research,
K Mortelmans, and S Haworth, and T Lawlor, and W Speck, and B Tainer, and E Zeiger
April 1966, Nature,
K Mortelmans, and S Haworth, and T Lawlor, and W Speck, and B Tainer, and E Zeiger
November 1980, Archives of toxicology,
K Mortelmans, and S Haworth, and T Lawlor, and W Speck, and B Tainer, and E Zeiger
April 2000, Mutation research,
K Mortelmans, and S Haworth, and T Lawlor, and W Speck, and B Tainer, and E Zeiger
January 1957, Rivista di medicina aeronautica,
K Mortelmans, and S Haworth, and T Lawlor, and W Speck, and B Tainer, and E Zeiger
January 1989, Reports on health and social subjects,
K Mortelmans, and S Haworth, and T Lawlor, and W Speck, and B Tainer, and E Zeiger
January 1983, Teratogenesis, carcinogenesis, and mutagenesis,
Copied contents to your clipboard!