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To characterize the erythrocyte insulin receptor in newborn infants we studied the binding of 125I-insulin to the erythrocytes from 42 preterm infants (14 at birth, 14 aged 2-7 days, and 14 aged 8-16 days) with a mean gestational age of 34.1 wk, and from 32 term infants (16 at birth and 16 aged 2-7 days). The insulin binding to cord blood erythrocytes from preterm infants was significantly higher than that of cord blood cells from term infants and to postnatal cells from preterm as well as term infants. The erythrocytes from preterm infants aged 2-7 days bound more insulin than cells from preterm infants aged 8-16 days. The maximum insulin binding (specific insulin binding at tracer concentration of insulin) correlated negatively with the gestational age both at birth and over the 1st postnatal wk. In the preterm infants there was a strong negative correlation between the maximum insulin binding and postnatal age. The enhanced insulin binding to cord blood erythrocytes from preterm infants was due to both an increased receptor concentration and a high affinity for insulin. The increased affinity persisted over the 1st wk of life. In preterm infants older than 1 wk the insulin binding characteristics were basically similar to those in term newborn infants. In all infants studied the receptor concentration seemed to be postnatal age dependent while the receptor affinity was gestational age dependent. No correlation was found between the insulin binding data and the plasma concentrations of immunoreactive insulin or C-peptide.(ABSTRACT TRUNCATED AT 250 WORDS)
R Puukka, and
M Knip, and
P Lautala, and
L Perkkilä, and
M Puukka
January 1977,
Rivista di neurologia,
R Puukka, and
M Knip, and
P Lautala, and
L Perkkilä, and
M Puukka
September 1989,
Anales espanoles de pediatria,
R Puukka, and
M Knip, and
P Lautala, and
L Perkkilä, and
M Puukka
January 1999,
Revista do Hospital das Clinicas,
R Puukka, and
M Knip, and
P Lautala, and
L Perkkilä, and
M Puukka
January 2007,
Hormone research,
R Puukka, and
M Knip, and
P Lautala, and
L Perkkilä, and
M Puukka
January 2004,
Jornal de pediatria,
R Puukka, and
M Knip, and
P Lautala, and
L Perkkilä, and
M Puukka
January 1983,
The American journal of pediatric hematology/oncology,
R Puukka, and
M Knip, and
P Lautala, and
L Perkkilä, and
M Puukka
June 1978,
Minerva pediatrica,
R Puukka, and
M Knip, and
P Lautala, and
L Perkkilä, and
M Puukka
July 2004,
European journal of pediatrics,
R Puukka, and
M Knip, and
P Lautala, and
L Perkkilä, and
M Puukka
January 1984,
AJNR. American journal of neuroradiology,
R Puukka, and
M Knip, and
P Lautala, and
L Perkkilä, and
M Puukka
May 1996,
Acta paediatrica (Oslo, Norway : 1992),
