-transparent.png){kind=logo}
An 11.5-year-old girl developed acute lymphoblastic leukaemia 7 months after bone marrow transplantation for severe aplastic anaemia. Before transplantation there were neither morphologic nor cytogenetic abnormalities to suggest preleukaemia. The conditioning regimen consisted only of cyclophosphamide. At the time of development of acute lymphoblastic leukaemia, chromosome analysis showed the blasts to be of host origin with clonal abnormalities including monosomy 7. Such a preleukaemic syndrome presenting as severe aplastic anaemia is a very rare event (the case reported here is the only one of 436 patients in Seattle) and cannot be reliably excluded before transplantation.
H G Klingemann, and
R Storb, and
J Sanders, and
H J Deeg, and
F R Appelbaum, and
E D Thomas
January 1978,
Triangle; the Sandoz journal of medical science,
H G Klingemann, and
R Storb, and
J Sanders, and
H J Deeg, and
F R Appelbaum, and
E D Thomas
May 1982,
Deutsche medizinische Wochenschrift (1946),
H G Klingemann, and
R Storb, and
J Sanders, and
H J Deeg, and
F R Appelbaum, and
E D Thomas
March 1988,
British journal of haematology,
H G Klingemann, and
R Storb, and
J Sanders, and
H J Deeg, and
F R Appelbaum, and
E D Thomas
January 1991,
Bone marrow transplantation,
H G Klingemann, and
R Storb, and
J Sanders, and
H J Deeg, and
F R Appelbaum, and
E D Thomas
January 1979,
Nouvelle revue francaise d'hematologie,
H G Klingemann, and
R Storb, and
J Sanders, and
H J Deeg, and
F R Appelbaum, and
E D Thomas
April 1990,
The Medical journal of Australia,
H G Klingemann, and
R Storb, and
J Sanders, and
H J Deeg, and
F R Appelbaum, and
E D Thomas
September 1983,
Lancet (London, England),
H G Klingemann, and
R Storb, and
J Sanders, and
H J Deeg, and
F R Appelbaum, and
E D Thomas
October 1982,
British journal of haematology,
H G Klingemann, and
R Storb, and
J Sanders, and
H J Deeg, and
F R Appelbaum, and
E D Thomas
June 1994,
Bailliere's clinical haematology,
H G Klingemann, and
R Storb, and
J Sanders, and
H J Deeg, and
F R Appelbaum, and
E D Thomas
October 1983,
Clinics in haematology,
