-transparent.png){kind=logo}
The interfering effect of sulphinpyrazone, a uricosuric agent which reduces the activity of cyclo-oxygenase, with the antihypertensive activity of oxprenolol, a non-cardioselective beta-blocker with sympathomimetic activity, has been evaluated. Ten patients with primary arterial hypertension of mild to moderate degree entered a randomized double-blind cross-over study versus placebo. They were given oxprenolol + placebo or oxprenolol + sulphinpyrazone for 15 days, and then the treatments were crossed-over for a further 15 days. Oxprenolol significantly reduced blood pressure (161 +/- 3/101 +/- 1 vs 149 +/- 4/96 +/- 2 mmHg) and heart rate (72 +/- 3 vs 66 +/- 3 beats/min). During administration of the combination with sulphinpyrazone the blood pressure increased to its pretreatment level (156 +/- 5/101 +/- 2 mmHg). The effect of oxprenolol on heart rate was not influenced by the combined treatment (67 +/- 6 beats/min). The results may be explained by 1) sulphinpyrazone-induced inhibition of prostaglandin synthesis, which could interfere with the antihypertensive activity of oxprenolol, or 2) sulphinpyrazone-induced acceleration of the metabolism of oxprenolol.
L A Ferrara, and
M Mancini, and
T Marotta, and
F Pasanisi, and
M L Fasano
August 1976,
Clinical pharmacology and therapeutics,
L A Ferrara, and
M Mancini, and
T Marotta, and
F Pasanisi, and
M L Fasano
June 1980,
Clinical pharmacology and therapeutics,
L A Ferrara, and
M Mancini, and
T Marotta, and
F Pasanisi, and
M L Fasano
January 2001,
Journal of inorganic biochemistry,
L A Ferrara, and
M Mancini, and
T Marotta, and
F Pasanisi, and
M L Fasano
March 1976,
Clinical pharmacology and therapeutics,
L A Ferrara, and
M Mancini, and
T Marotta, and
F Pasanisi, and
M L Fasano
October 1975,
British journal of pharmacology,
L A Ferrara, and
M Mancini, and
T Marotta, and
F Pasanisi, and
M L Fasano
January 1976,
Current therapeutic research, clinical and experimental,
L A Ferrara, and
M Mancini, and
T Marotta, and
F Pasanisi, and
M L Fasano
January 1971,
Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
L A Ferrara, and
M Mancini, and
T Marotta, and
F Pasanisi, and
M L Fasano
January 1984,
Clinical therapeutics,
L A Ferrara, and
M Mancini, and
T Marotta, and
F Pasanisi, and
M L Fasano
January 1982,
Pharmatherapeutica,
L A Ferrara, and
M Mancini, and
T Marotta, and
F Pasanisi, and
M L Fasano
April 1987,
Archives des maladies du coeur et des vaisseaux,
