Barriers and Factors Associated with HPV Vaccination Among American Indians and Alaska Natives: A Systematic Review. 2022

Sameer V Gopalani, and Ami E Sedani, and Amanda E Janitz, and Shari C Clifton, and Jennifer D Peck, and Ashley Comiford, and Janis E Campbell
Department of Biostatistics and Epidemiology, Hudson College of Public Health, University of Oklahoma Health Sciences Center, 801 N.E. 13th Street, Oklahoma City, OK, 73104, USA. sameer-gopalani@ouhsc.edu.

American Indian and Alaska Native (AI/AN) persons bear a disproportionate burden of human papillomavirus (HPV)-associated cancers and face unique challenges to HPV vaccination. We undertook a systematic review to synthesize the available evidence on HPV vaccination barriers and factors among AI/AN persons in the United States. We searched fourteen bibliographic databases, four citation indexes, and six gray literature sources from July 2006 to January 2021. We did not restrict our search by study design, setting, or publication type. Two reviewers independently screened the titles and abstracts (stage 1) and full-text (stage 2) of studies for selection. Both reviewers then independently extracted data using a data extraction form and undertook quality appraisal and bias assessment using the modified Mixed Methods Appraisal Tool. We conducted thematic synthesis to generate descriptive themes. We included a total of 15 records after identifying 3017, screening 1415, retrieving 203, and assessing 41 records. A total of 21 unique barriers to HPV vaccination were reported across 15 themes at the individual (n = 12) and clinic or provider (n = 3) levels. At the individual level, the most common barriers to vaccination-safety and lack of knowledge about the HPV vaccine-were each reported in the highest number of studies (n = 9; 60%). The findings from this review signal the need to develop interventions that target AI/AN populations to increase the adoption and coverage of HPV vaccination. Failure to do so may widen disparities.

UI MeSH Term Description Entries
D007198 Indians, North American Members of indigenous North American populations with pre-colonial contact origins. Amerinds, North American,Indigenous North Americans,American Indian, North,American, Indigenous North,Amerind, North American,Indian, North American,Indigenous North American,North American Amerind,North American Amerinds,North American Indian,North American Indians,North American, Indigenous
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000072957 Alaska Natives Persons having origins in any indigenous people of ALASKA and their descendants. Alaskan Natives,Indigenous Alaskans,Native Alaskans,Alaska's Indigenous People,Indigenous People of Alaska,Alaska Indigenous People,Alaska Indigenous Peoples,Alaska Native,Alaska's Indigenous Peoples,Alaskan Native,Alaskan, Indigenous,Alaskan, Native,Alaskans, Indigenous,Alaskans, Native,Alaskas Indigenous People,Indigenous Alaskan,Indigenous People, Alaska's,Indigenous Peoples, Alaska's,Native Alaskan,Native, Alaskan,Natives, Alaska,Natives, Alaskan,People, Alaska's Indigenous,Peoples, Alaska's Indigenous
D014481 United States A country in NORTH AMERICA between CANADA and MEXICO.
D014611 Vaccination Administration of vaccines to stimulate the host's immune response. This includes any preparation intended for active immunological prophylaxis. Immunization, Active,Active Immunization,Active Immunizations,Immunizations, Active,Vaccinations
D044467 American Indian or Alaska Native A person having origins in any of the original peoples of North, South and Central Americas, and who maintains tribal affiliation or community attachment (https://www.federalregister.gov/documents/1997/10/30/97-28653/revisions-to-the-standards-for-the-classification-of-federal-data-on-race-and-ethnicity). In the United States it is used for classification of federal government data on race and ethnicity. Race and ethnicity terms are self-identified social construct and may include terms outdated and offensive in MeSH to assist users who are interested in retrieving comprehensive search results for studies such as in longitudinal studies. American Indians,American Indians or Alaska Natives,American Native Continental Ancestry Group,American Natives,Indians, American,Native Americans,Native Americans, Federally-Recognized,American Indian,American Native,American, Native,Federally-Recognized Native American,Federally-Recognized Native Americans,Native American,Native American, Federally-Recognized,Native, American
D053918 Papillomavirus Vaccines Vaccines or candidate vaccines used to prevent PAPILLOMAVIRUS INFECTIONS. Human vaccines are intended to reduce the incidence of UTERINE CERVICAL NEOPLASMS, so they are sometimes considered a type of CANCER VACCINES. They are often composed of CAPSID PROTEINS, especially L1 protein, from various types of ALPHAPAPILLOMAVIRUS. HPV Vaccine,Human Papilloma Virus Vaccine,Human Papillomavirus Vaccine,Human Papillomavirus Vaccines,Papillomavirus Vaccine,HPV Vaccines,Human Papilloma Virus Vaccines,Papillomavirus Vaccine, Human,Papillomavirus Vaccines, Human,Vaccine, HPV,Vaccine, Human Papillomavirus,Vaccine, Papillomavirus,Vaccines, Human Papillomavirus,Vaccines, Papillomavirus
D030361 Papillomavirus Infections Neoplasms of the skin and mucous membranes caused by papillomaviruses. They are usually benign but some have a high risk for malignant progression. HPV Infection,Human Papillomavirus Infection,HPV Infections,Human Papillomavirus Infections,Papillomavirus Infection,Papillomavirus Infection, Human,Papillomavirus Infections, Human

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