-transparent.png){kind=logo}
Gallstone dissolution and biliary lipids were determined and compared in patients receiving either chenodeoxycholic acid (CDC), or CDC and phenobarbital (PB) for 11/2 to 2 years. Among patients with radiolucent gallstones, dissolution occurred in 53% of those receiving CDC alone and in only 25% of those receiving both CDC and PB. No dissolution occurred in 13 other patients with calcified gallstones. Patients with dissolution had a significantly greater molar percentage of CDC and a significantly lower saturation index in bile than those without dissolution. Diarrhea and transiently abnormal liver function tests were the most frequently observed side-effects but only diarrhea necessitated a reduction of the CDC dose. Gallstones recurred following dissolution in one of six patients followed for six months after discontinuation of CDC. In conclusion, PB did not enhance CDC-induced desaturation of bile or gallstone dissolution.
J W Marks, and
J H Sherman, and
G G Bonorris, and
A Chung, and
M J Coyne, and
L J Schoenfield
February 1973,
Lancet (London, England),
J W Marks, and
J H Sherman, and
G G Bonorris, and
A Chung, and
M J Coyne, and
L J Schoenfield
January 1973,
Lancet (London, England),
J W Marks, and
J H Sherman, and
G G Bonorris, and
A Chung, and
M J Coyne, and
L J Schoenfield
August 1978,
Lancet (London, England),
J W Marks, and
J H Sherman, and
G G Bonorris, and
A Chung, and
M J Coyne, and
L J Schoenfield
December 1972,
Lancet (London, England),
J W Marks, and
J H Sherman, and
G G Bonorris, and
A Chung, and
M J Coyne, and
L J Schoenfield
March 1980,
Klinische Wochenschrift,
J W Marks, and
J H Sherman, and
G G Bonorris, and
A Chung, and
M J Coyne, and
L J Schoenfield
June 1977,
The American journal of clinical nutrition,
J W Marks, and
J H Sherman, and
G G Bonorris, and
A Chung, and
M J Coyne, and
L J Schoenfield
April 1992,
Digestive diseases and sciences,
J W Marks, and
J H Sherman, and
G G Bonorris, and
A Chung, and
M J Coyne, and
L J Schoenfield
May 1978,
Lancet (London, England),
J W Marks, and
J H Sherman, and
G G Bonorris, and
A Chung, and
M J Coyne, and
L J Schoenfield
October 1973,
Gut,
J W Marks, and
J H Sherman, and
G G Bonorris, and
A Chung, and
M J Coyne, and
L J Schoenfield
May 1976,
The American journal of digestive diseases,
